ArticleNature2022
The tethered peptide activation mechanism of adhesion GPCRs.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
82 citing papers in PubMed, 149 citations in OpenAlex.
- The isolated Stachel peptide of the adhesion G protein-coupled receptor ADGRG6 is predominantly disordered with local helical propensity.Biophysical journal · 2026Article
- The human cytomegalovirus vGPCR UL33 is essential for efficient lytic replication in epithelial cells.Journal of virology · 2026Article
- Review
- Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR.Science advances · 2026Article
- Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation.Nature chemical biology · 2026Article
- Tethered agonist- and GAIN domain-independent signaling of an adhesion GPCR.Science advances · 2026Article
- Molecular continuity between axon guidance and synaptic function.Molecules and cells · 2026Review
- Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Adhesion G protein-coupled receptors.Pharmacological reviews · 2026Review
- Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors.Nature communications · 2026Article
- The Role of the TG2-GPR56 Complex in Cutaneous Squamous Cell Carcinoma (CSCC) Aggression and Therapeutic Resistance.International journal of molecular sciences · 2026Review
- Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2.Cell chemical biology · 2026Article
- aGPCR-HEK: A Stable High-Expression Inducible Mammalian Cell Expression System for Adhesion GPCR Structural Biology Applications.Bio-protocol · 2026Article
- Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide.Communications biology · 2026Article
- Extra-helical allosteric binding site of apomorphine in ADGRG6.Cell discovery · 2026Article
- Biallelic variants in CELSR1 cause brain malformations, neurodevelopmental disorders and epilepsy in humans.Nature communications · 2026Article
- Synaptic Cell Adhesion: A Structural Perspective.Advances in neurobiology · 2026Review
- Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling.Nature metabolism · 2026Article
- Structure of the GNature communications · 2025Article
- G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa.eLife · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 4 institutions in 2 countries.
Ximena Barros-Álvarez *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6678-9436
Robert M Nwokonko *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Alexander Vizurraga *Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, USA.
Donna Matzov *Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Feng HeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Makaía M Papasergi-ScottDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3238-3213
Michael J RobertsonDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2610-680X
Ouliana PanovaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Eliane Hadas YardeniDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Alpay B SevenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Frank E KwarcinskiDepartment of Pharmacology, University of Michigan School of Medicine, Ann Arbor, USA.
Hongyu SuDepartment of Pharmacology, University of Michigan School of Medicine, Ann Arbor, USA.
Maria Claudia PerotoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Justin G MeyerowitzDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7194-8286
Moran Shalev-BenamiDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel. moransb@weizmann.ac.il.
Gregory G TallDepartment of Pharmacology, University of Michigan School of Medicine, Ann Arbor, USA. gregtall@med.umich.edu.ORCID http://orcid.org/0000-0002-6540-4896
Georgios SkiniotisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.ORCID http://orcid.org/0000-0003-0238-7846
Stanford University · USUniversity of Michigan · USWeizmann Institute of Science · ILStanford Medicine · US
Funding
Regulation of Heterotrimeric G proteins by non-receptor activatorsR01GM088242 · NIGMS · UNIVERSITY OF ROCHESTER · PI TALL, GREGORY GORDON · 2009 to 2022
$4.2MMechanisms of Adhesion GPCR ActionR01GM120110 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TALL, GREGORY GORDON · 2016 to 2023
$2.4MInvestigation of Adhesion GPCR and Ric-8 protein control of heterotrimeric G proteinsR35GM149539 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory Gordon Tall · 2023 to 2026
$2.1MDevelopment of Chemical Probes to Investigate Adhesion GPCR Tethered AgonismR01NS103946 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TALL, GREGORY GORDON · 2018 to 2021
$1.7MNew pharmacological tools to explore platelet GPR56 functionF31HL152563 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VIZURRAGA, ALEXANDER · 2020 to 2022
$106kEuropean Research CouncilNHLBI NIH HHS F31 HL152563NIGMS NIH HHS R01 GM088242NIGMS NIH HHS R01 GM120110NIGMS NIH HHS R35 GM149539NINDS NIH HHS R01 NS103946
Abstract
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions
Indexed as
Receptors, G-Protein-CoupledSignal TransductionCell AdhesionCell MembraneCryoelectron MicroscopyHumansPeptidesProtein BindingReceptors, PeptideADGRG1 protein, humanADGRL3 protein, humanPeptidesReceptors, G-Protein-CoupledReceptors, Peptide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.