Evidence map›Paper›PMID 35418597›Full record

ArticleScientific reports2022

Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells.

Richard A Seidman, Heba Khattab, Jessie J Polanco, Jacqueline E Broome, Fraser J Sim

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Richard A SeidmanNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Heba KhattabDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY, 14203, USA.
Jessie J PolancoNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Jacqueline E BroomeDepartment of Pharmacology and Toxicology, Jacob's School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY, 14203, USA.
Fraser J SimNeuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. fjsim@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Muscarinic Receptor Type 3 Regulation of Oligodendrocyte Progenitor DifferentiationR01NS104021 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2018 to 2022
$1.7M
NCATS NIH HHS UL1 TR001412NCATS NIH HHS UL1TR001412-S1NIGMS NIH HHS R25GM09545902NINDS NIH HHS R01 NS104021NINDS NIH HHS R01NS104021
6 · The paper itself

Abstract

Endogenous remyelination in demyelinating diseases such as multiple sclerosis is contingent upon the successful differentiation of oligodendrocyte progenitor cells (OPCs). Signaling via the Gα

Indexed as

Calcium SignalingOligodendrocyte Precursor CellsCalciumCalcium, DietaryHumansMuscarinic AgonistsORAI1 ProteinRNA, Small InterferingStromal Interaction Molecule 1Stromal Interaction Molecule 2CalciumCalcium, DietaryMuscarinic AgonistsORAI1 ProteinRNA, Small InterferingStromal Interaction Molecule 1Stromal Interaction Molecule 2

Identifiers

PMID35418597
PMCPMC9007940
OpenAlexW4226256664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.