Evidence map›Paper›PMID 35418488›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2022

COVID-19 and tuberculosis: the double whammy of respiratory pathogens.

Mohd Shariq, Javaid A Sheikh, Neha Quadir, Neha Sharma, Seyed E Hasnain, Nasreen Z Ehtesham

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Prevalence of Long COVID inJournal of clinical tuberculosis and other mycobacterial diseases · 2026
    Article
  3. Article
  4. Lived experiences of tuberculosis patients accessing treatment during COVID-19 in Zimbabwe.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Post-COVID-19 tuberculosis in southeastern Spain: incidence, risk factors and the role of latent tuberculosis infection screening.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Applying Multiple Analyses to Quantify Changes in the Global, Regional, and National Burden of Tuberculosis From 1990 to 2021 and the Forecast Until 2035.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  18. Article
  19. Drug resistance profiles ofJAC-antimicrobial resistance · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mohd ShariqICMR-National Institute of Pathology, New Delhi, India.
Javaid A SheikhDept of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
Neha QuadirICMR-National Institute of Pathology, New Delhi, India.
Neha SharmaICMR-National Institute of Pathology, New Delhi, India.
Seyed E HasnainDept of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi, India.
Nasreen Z EhteshamICMR-National Institute of Pathology, New Delhi, India nasreen.ehtesham@nip.gov.in.
Jamia Hamdard · INNational Institute of Pathology · INInstitute of Molecular Medicine · INSharda University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prior to coronavirus disease 2019 (COVID-19), tuberculosis (TB) was the worst killer among infectious diseases. The union of these two obnoxious respiratory diseases can be devastating, with severe public health implications. The COVID-19 pandemic has affected all TB-elimination programmes due to the severe burden on healthcare systems and the diversion of funds and attention towards controlling the pandemic. The emerging data show that the COVID-19 pandemic caused a marked decrease in case notifications and bacille Calmette-Guérin immunisations, ultimately promoting disease transmission and increasing the susceptible population. The similarity between the clinical characteristics of TB and COVID-19 adds to the public health complications, with evidence of immune dysregulation in both cases leading to severe consequences. Clinical evidence suggests that severe acute respiratory syndrome coronavirus 2 infection predisposes patients to TB infection or may lead to reactivation of latent disease. Similarly, underlying TB disease can worsen COVID-19. Treatment options are limited in COVID-19; therefore, using immunosuppressive and immunomodulatory regimens that can modulate the concomitant bacterial infection and interaction with anti-TB drugs requires caution. Thus, considering the synergistic impact of these two respiratory diseases, it is crucial to manage both diseases to combat the syndemic of TB and COVID-19.

Indexed as

COVID-19TuberculosisAntitubercular AgentsHumansPandemicsSARS-CoV-2Antitubercular Agents

Identifiers

PMID35418488
PMCPMC9488123
OpenAlexW4224102052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.