ArticleNeurology2022
Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults.
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.Journal of Alzheimer's disease : JAD · 2025Trial
- Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial.Journal of the American Heart Association · 2023Trial
- Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial.American journal of hypertension · 2023Trial
- Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Article
- Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review
- Blood pressure dynamic instability and neurodegeneration in older adults.Journal of Alzheimer's disease : JAD · 2025Article
- Blood Pressure Postural Changes Variability Is Associated With Lower Cognition: The S.AGES Cohort.Journal of the American Heart Association · 2025Article
- Association Between Short-Term Blood Pressure Variability and the Alzheimer's Disease Continuum.Brain and behavior · 2025Article
- The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art.Cerebral circulation - cognition and behavior · 2025Article
- Beyond Hypertension: Examining Variable Blood Pressure's Role in Cognition and Brain Structure.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Reliability of beat-to-beat blood pressure variability in older adults.Scientific reports · 2024Article
- Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults.Alzheimer's research & therapy · 2024Article
- Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small-Vessel Disease inJournal of the American Heart Association · 2024Article
- Hypertension, Neurodegeneration, and Cognitive Decline.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease.Aging and disease · 2024Review
- Reliability of beat-to-beat blood pressure variability in older adults.Research square · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesBlood pressure variability is an emerging risk factor for cognitive decline and dementia, but mechanisms remain unclear. The current study examined whether visit-to-visit blood pressure variability is related to CSF Alzheimer disease biomarker levels over time and whether associations differed by
methodsIn this retrospective analysis of a prospective cohort study, cognitively unimpaired or mildly impaired older adults from the Alzheimer's Disease Neuroimaging Initiative underwent 3 to 4 blood pressure measurements over a 12-month period and ≥1 lumbar puncture for evaluation of CSF phosphorylated tau, total tau, and β-amyloid levels at follow-up (6-108 months later).
resultsFour hundred sixty-six participants (mean 76.7 [SD 7.1] years of age) were included in the study. Elevated blood pressure variability was associated with increased CSF phosphorylated tau (β = 0.81 [95% CI 0.74, 0.97]), increased total tau (β = 0.98 [95% CI 0.71, 1.31]), and decreased β-amyloid levels (β = -1.52 [95% CI -3.55, -0.34]) at follow-up. DISCUSSION: Older adults with elevated blood pressure variability exhibit increased CSF phosphorylated tau, increased total tau, and decreased β-amyloid over time, suggesting that blood pressure variability may correlate with alterations in Alzheimer disease biomarkers. Findings warrant further study of the relationship between blood pressure variability and the development of Alzheimer disease.
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