Evidence map›Paper›PMID 35418456›Full record

ArticleNeurology2022

Association of Motor and Nonmotor Symptoms With Health-Related Quality of Life in a Large Online Cohort of People With Parkinson Disease.

Meredith A Bock, Ethan G Brown, Li Zhang, Caroline Tanner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  3. Health-related quality of life in Parkinson's disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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  6. What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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  7. Plant-derived therapies in Parkinson's disease: a systematic review of clinical evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meredith A BockFrom the Movement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neuroscience (M.A.B., E.G.B., C.T.), and Departments of Medicine (L.Z.) and Epidemiology and Biostatistics (L.Z.), University of California, San Francisco; and Mental Illness Research, Education, and Clinical Center (M.A.B.) and Parkinson's Disease Research Education and Clinical Center (C.T.), San Francisco Veterans Affairs Health Care System, CA. meredith.bock@ucsf.edu.
Ethan G BrownFrom the Movement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neuroscience (M.A.B., E.G.B., C.T.), and Departments of Medicine (L.Z.) and Epidemiology and Biostatistics (L.Z.), University of California, San Francisco; and Mental Illness Research, Education, and Clinical Center (M.A.B.) and Parkinson's Disease Research Education and Clinical Center (C.T.), San Francisco Veterans Affairs Health Care System, CA.
Li ZhangFrom the Movement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neuroscience (M.A.B., E.G.B., C.T.), and Departments of Medicine (L.Z.) and Epidemiology and Biostatistics (L.Z.), University of California, San Francisco; and Mental Illness Research, Education, and Clinical Center (M.A.B.) and Parkinson's Disease Research Education and Clinical Center (C.T.), San Francisco Veterans Affairs Health Care System, CA.
Caroline TannerFrom the Movement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neuroscience (M.A.B., E.G.B., C.T.), and Departments of Medicine (L.Z.) and Epidemiology and Biostatistics (L.Z.), University of California, San Francisco; and Mental Illness Research, Education, and Clinical Center (M.A.B.) and Parkinson's Disease Research Education and Clinical Center (C.T.), San Francisco Veterans Affairs Health Care System, CA.
Geriatric Research Education and Clinical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere is growing interest in health-related quality of life (HRQOL) as a comprehensive view of the patient's well-being, guiding concept for the treating clinician, and therapeutic trial outcome measure for patients with Parkinson disease (PwPD). The key determinants of HRQOL have not been investigated in large populations of PwPD. Our objective was to evaluate correlates of HRQOL in a large, online cohort of PwPD.

methodsAs part of an ongoing online cohort study, we performed a cross-sectional analysis at enrollment of 23,058 PwPD. We conducted univariate and stepwise multivariate linear regression analyses of HRQOL as measured by the EQ-5D-5L tool. In addition, we performed an interaction analysis to evaluate heterogeneity of the effect of motor symptoms on HRQOL and Spearman correlation analysis to evaluate the association of nonmotor symptoms with HRQOL.

resultsIn the multivariate linear regression model, participants with moderate or severe depression, more severe motor symptoms, and a higher burden of medical comorbidities had the most substantially decreased HRQOL as measured by the EQ index (β -0.11, -0.18, -0.02, -0.01, respectively; DISCUSSION: Potentially treatable motor and nonmotor symptoms, particularly neuropsychiatric symptoms, account for a large amount of the variation in HRQOL in PwPD. Motor symptoms may have differential effects on HRQOL in different demographic and clinical subpopulations, highlighting important areas for future health disparities research. Our findings provide targets for clinician intervention and future research on symptom management to optimize HRQOL in PD. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that motor and neuropsychiatric symptoms are associated with HRQOL in PwPD.

Indexed as

Cognitive DysfunctionParkinson DiseaseCohort StudiesCross-Sectional StudiesFemaleHumansQuality of LifeSurveys and Questionnaires

Identifiers

PMID35418456
PMCPMC9162165
OpenAlexW4224093208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.