Evidence map›Paper›PMID 35418450›Full record

ArticleNeurology2022

Progressive Worsening of Gait and Motor Abnormalities in Older Adults With Dravet Syndrome.

Arunan Selvarajah, Carolina Gorodetsky, Paula Marques, Quratulain Zulfiqar Ali, Anne T Berg, Alfonso Fasano, Danielle M Andrade

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  15. Adult Phenotype ofNeurology. Genetics · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arunan SelvarajahFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-6712-3940
Carolina GorodetskyFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-0007-9591
Paula MarquesFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-1303-9273
Quratulain Zulfiqar AliFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-3984-5276
Anne T BergFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-0298-5523
Alfonso FasanoFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-5346-0180
Danielle M AndradeFrom the Institute of Medical Science, Faculty of Medicine (A.S., C.G., A.F., D.M.A.), and Division of Neurology, Department of Medicine (P.M., A.F., D.M.A.), University of Toronto; Adult Epilepsy Genetics Program, Department of Neurology, Krembil Research Institute (A.S., P.M., Q.Z.A., D.M.A.), and Krembil Brain Institute (C.G., A.F., D.M.A.), University Health Network, and Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic (C.G., A.F.), Toronto Western Hospital; Pediatric Neurology (C.G.), The Hospital for Sick Children, Toronto, Canada; Division of Neurology, Epilepsy Center (A.T.B.), Ann & Robert H. Lurie Children's Hospital of Chicago; and Department of Pediatrics (A.T.B.), Northwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-0953-2698
MACOM (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesRelative to the pediatric population, there is limited information about Dravet syndrome (DS) in adults. In addition to some of the gait abnormalities reported in children with DS (such as crouch gait and ataxia), adults with this condition have other gait and motor disturbances. Our primary objective was to examine gait and motor manifestations in adults with DS.

methodsThis study includes a prospective arm where 6 patients (mean age, 32 years) were examined through a modified version of the Unified Parkinson's Disease Rating Scale (mUPDRS) in 2014 and again in 2019. mUPDRS scores were assigned to gait, resting tremors, facial expression, arising from a chair, posture, and body bradykinesia. The cross-sectional arm includes mUPDRS testing in patients who were not evaluated in 2014 and an instrumental gait analysis (IGA). These cross-sectional tests were done in the 2019-2020 period. The IGA was performed using ProtoKinetics software with a gait mat built with sensors and 2 cameras capturing the sagittal and coronal planes. The IGA was performed in a group of 17 patients with DS (mean age, 31 years); the control group consisted of 81 healthy individuals, whose mean age was 62 years. Regression analyses were performed for the IGA and mUPDRS data.

resultsFive out of 6 participants evaluated prospectively over 5 years experienced worsening of their parkinsonian manifestations, including gait. Two patients (47 and 51 years of age) who were initially ambulatory could no longer walk 5 years later. The cross-sectional analysis of mUPDRS in a larger group of adults showed that worse scores for arising from a chair ( DISCUSSION: Although seizures may decrease in older adults with DS, this prospective and cross-sectional study showed that their motor symptoms and gait become progressively worse as they age.

Indexed as

Epilepsies, MyoclonicHypokinesiaAdultAgedChildChild, PreschoolCross-Sectional StudiesEpileptic SyndromesGaitHumansImmunoglobulin AMiddle AgedProspective StudiesSpasms, InfantileImmunoglobulin A

Identifiers

PMID35418450
PMCPMC9162168
OpenAlexW4224018044

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.