ArticleBMJ (Clinical research ed.)2022
Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study.
Article in BMJ (Clinical research ed.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Blueberries for brainpower: A systematic review and meta-analysis with Bayesian post hoc analysis of RCTS exploring cognitive function in the elderly with prior cognitive decline.Biogerontology · 2025Pooled it
- Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer's Disease and Dementia: A Systematic Review.Nutrients · 2025Pooled it
- Pooled it
- Measuring and increasing the brain health span across adulthood: a public health imperative.Scientific reports · 2026Trial
- Structured exercise, cognitive-social engagement, and cognitive impairment-free life expectancy across four longitudinal aging cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- How a healthy lifestyle mediates socioeconomic inequities in healthy ageing and life expectancies: A 20-year cohort of older adults.Fundamental research · 2026Article
- Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder.Nature communications · 2026Article
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- The Effect of Parenthood on Health Lifestyles: A Longitudinal Analysis Using Data from the German Socio-Economic Panel.International journal of environmental research and public health · 2026Article
- LifeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Time in target systolic blood pressure range and cardiometabolic disease-free life expectancy in hypertensive elderly.American journal of preventive cardiology · 2026Article
- Article
- Prevention of dementia using mobile phone applications (PRODEMOS) - a health-economic cost-utility analysis in people aged 55-75 years with low socio-economic status.The journal of prevention of Alzheimer's disease · 2026Article
- Review
- Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks.Behavior research methods · 2026Article
- Causal machine learning analysis identifies subpopulations most likely to benefit from healthy lifestyles for cognitive outcomes.General psychiatry · 2026Article
- The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR).PLoS medicine · 2026Article
- GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging.Research square · 2026Article
- Key pillars of active aging in the context of the Decade of Healthy Ageing (2021-2030): an integrative literature review.Dementia & neuropsychologia · 2026Article
- Soluble fermentable dietary fiber attenuates age-related cognitive impairment via neuroimmune and antioxidant modulation: evidence from multilevel analyses in populations and aging mouse models.Frontiers in immunology · 2026Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo determine the impact of lifestyle factors on life expectancy lived with and without Alzheimer's dementia.
designProspective cohort study.
settingThe Chicago Health and Aging Project, a population based cohort study in the United States.
participants2449 men and women aged 65 years and older. MAIN EXPOSURE: A healthy lifestyle score was developed based on five modifiable lifestyle factors: a diet for brain health (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay-MIND diet score in upper 40% of cohort distribution), late life cognitive activities (composite score in upper 40%), moderate or vigorous physical activity (≥150 min/week), no smoking, and light to moderate alcohol consumption (women 1-15 g/day; men 1-30 g/day). MAIN OUTCOME: Life expectancy with and without Alzheimer's dementia in women and men.
resultsWomen aged 65 with four or five healthy factors had a life expectancy of 24.2 years (95% confidence interval 22.8 to 25.5) and lived 3.1 years longer than women aged 65 with zero or one healthy factor (life expectancy 21.1 years, 19.5 to 22.4). Of the total life expectancy at age 65, women with four or five healthy factors spent 10.8% (2.6 years, 2.0 to 3.3) of their remaining years with Alzheimer's dementia, whereas women with zero or one healthy factor spent 19.3% (4.1 years, 3.2 to 5.1) with the disease. Life expectancy for women aged 65 without Alzheimer's dementia and four or five healthy factors was 21.5 years (20.0 to 22.7), and for those with zero or one healthy factor it was 17.0 years (15.5 to 18.3). Men aged 65 with four or five healthy factors had a total life expectancy of 23.1 years (21.4 to 25.6), which is 5.7 years longer than men aged 65 with zero or one healthy factor (life expectancy 17.4 years, 15.8 to 20.1). Of the total life expectancy at age 65, men with four or five healthy factors spent 6.1% (1.4 years, 0.3 to 2.0) of their remaining years with Alzheimer's dementia, and those with zero or one healthy factor spent 12.0% (2.1 years, 0.2 to 3.0) with the disease. Life expectancy for men aged 65 without Alzheimer's dementia and four or five healthy factors was 21.7 years (19.7 to 24.9), and for those with zero or one healthy factor life expectancy was 15.3 years (13.4 to 19.1).
conclusionA healthy lifestyle was associated with a longer life expectancy among men and women, and they lived a larger proportion of their remaining years without Alzheimer's dementia. The life expectancy estimates might help health professionals, policy makers, and stakeholders to plan future healthcare services, costs, and needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.