Evidence map›Paper›PMID 35418262›Full record

ArticleMolecular pain

Extracellular signal-regulated kinase phosphorylation enhancement and Na

Kotaro Hidaka, Toyoaki Maruta, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Satoshi Kouroki, Tetsuro Shirasaka, Ryu Takeya, Isao Tsuneyoshi

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [Safety and efficacy of pulsed radiofrequency therapy for zoster-associated trigeminal neuralgia under general anesthesia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  5. Article
  6. Review
  7. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  8. Article
  9. An Overview of the Mechanisms Involved in Neuralgia.Journal of inflammation research · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kotaro HidakaFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
Toyoaki MarutaFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.ORCID 0000-0002-2660-2179
Tomohiro KoshidaFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
Mio KurogiFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
Yohko KageFaculty of Medicine, Department of Pharmacology, 12952University of Miyazaki, Miyazaki, Japan.
Satoshi KourokiFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
Tetsuro ShirasakaFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
Ryu TakeyaFaculty of Medicine, Department of Pharmacology, 12952University of Miyazaki, Miyazaki, Japan.
Isao TsuneyoshiFaculty of Medicine, Department of Anesthesiology, 12952University of Miyazaki, Miyazaki, Japan.
University of Miyazaki · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulsed radiofrequency (PRF) therapy is one of the most common treatment options for neuropathic pain, albeit the underlying mechanism has not been hitherto elucidated. In this study, we investigated the efficacy and mechanism of PRF therapy on resiniferatoxin (RTX)-induced mechanical allodynia, which has been used as a model of postherpetic neuralgia (PHN). Adult male rats were intraperitoneally injected with a vehicle or RTX. Furthermore, PRF current was applied on a unilateral sciatic nerve in all RTX-treated rats. On both ipsilateral and contralateral sides, the paw mechanical withdrawal thresholds were examined and L4-6 dorsal root ganglia (DRG) were harvested. In the DRG of rats with RTX-induced mechanical allodynia, Na

Indexed as

Extracellular Signal-Regulated MAP KinasesNAV1.7 Voltage-Gated Sodium ChannelNeuralgiaNeuralgia, PostherpeticRadiofrequency TherapyTramadolAnimalsDiterpenesGanglia, SpinalHumansHyperalgesiaMaleNeuronsPhosphorylationRatsRats, Sprague-DawleyDiterpenesExtracellular Signal-Regulated MAP KinasesNAV1.7 Voltage-Gated Sodium ChannelresiniferatoxinScn9a protein, ratSodium ChannelsTramadolERK phosphorylationNaV1.7postherpetic neuralgiapulsed radiofrequencyresiniferatoxin

Identifiers

PMID35418262
PMCPMC9019323
OpenAlexW4223927157

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.