ArticleFluids and barriers of the CNS2022
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid.
Article in Fluids and barriers of the CNS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Correction: Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid.Fluids and barriers of the CNS · 2025Article
- Advection and diffusion in perivascular and extracellular spaces in the brain.Journal of the Royal Society, Interface · 2025Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- Mouse brain elastography changes with sleep/wake cycles, aging, and Alzheimer's disease.NeuroImage · 2024Article
- Modeling of brain efflux: Constraints of brain surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gaps in the wall of a perivascular space act as valves to produce a directed flow of cerebrospinal fluid: a hoop-stress model.Journal of the Royal Society, Interface · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.Frontiers in cellular neuroscience · 2024Review
- Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.Journal of the Royal Society, Interface · 2023Article
- Sizes and shapes of perivascular spaces surrounding murine pial arteries.Fluids and barriers of the CNS · 2023Article
- Ependyma in Neurodegenerative Diseases, Radiation-Induced Brain Injury and as a Therapeutic Target for Neurotrophic Factors.Biomolecules · 2023Review
- Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.Research square · 2023Article
- Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Transport Mechanisms at the Blood-Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs.Pharmaceutics · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Clearance of protein waste products from the brain is accomplished by a combination of advection and diffusion in cerebrospinal fluid (CSF) and interstitial fluid (ISF). In the glymphatic model, there is a flow of ISF in the interstitial space, and both advection and diffusion occur there. Such a flow of ISF would be slow and difficult to detect directly, and its existence has proved controversial. Waste clearance has been shown to occur mainly during sleep, during which the volume of the interstitial space increases substantially due to ISF emitted from astrocytes. Here I show that this volume increase of the interstitial space, by itself, should lead to a slight reduction of diffusive transport, due to dilution of the waste solute, but to a significant increase in flow rate and advective transport, due to lowered hydraulic resistance. Thus, a flow of ISF together with the observed volume increase of the interstitial space might provide an important mechanism contributing to the enhanced clearance during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.