Evidence map›Paper›PMID 35417845›Full record

ArticleEBioMedicine2022

Air pollution and risk of chronic obstructed pulmonary disease: The modifying effect of genetic susceptibility and lifestyle.

Lulin Wang, Junqing Xie, Yonghua Hu, Yaohua Tian

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Review
  3. Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
  5. Review
  6. Article
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  12. Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lulin WangMinistry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China; Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China.
Junqing XieCenter for Statistics in Medicine, NDORMS, University of Oxford, The Botnar Research Centre, Oxford, UK.
Yonghua HuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38 Xueyuan Road, Beijing 100191, China.
Yaohua TianMinistry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China; Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan 430030, China. Electronic address: yaohua_tian@hust.edu.cn.
Huazhong University of Science and Technology · CNPeking University · CNUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundThe effect of long-term exposure to air pollution on the development of chronic obstructive pulmonary disease (COPD) is still controversial, and the role of the interactions of air pollution with genetic risk and lifestyle in COPD risk is unclear.

methodsWe included 452762 participants derived from the UK Biobank. Annual concentrations of air pollutions, including particle matter (PM

findingsEach interquartile range (IQR) increase in annual concentrations of PM

interpretationLong-term exposure to air pollution was associated with increased risk of COPD, especially in those with high genetic risk and unfavourable lifestyle.

fundingNone.

Indexed as

Air PollutantsAir PollutionPulmonary Disease, Chronic ObstructiveEnvironmental ExposureGenetic Predisposition to DiseaseHumansLife StyleNitrogen DioxideParticulate MatterAir PollutantsNitrogen DioxideParticulate MatterAir pollutionChronic obstructive pulmonary diseaseGenetic susceptibilityLifestyle

Identifiers

PMID35417845
PMCPMC9018147
OpenAlexW4223494522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.