Evidence map›Paper›PMID 35417754›Full record

ArticleNeuroImage2022

Resolution and b value dependent structural connectome in ex vivo mouse brain.

Stephanie Crater, Surendra Maharjan, Yi Qi, Qi Zhao, Gary Cofer, James C Cook, G Allan Johnson, Nian Wang

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Diffusion MRI reveals amyloid plaque-associated cellular signatures through spatial transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  5. From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  15. Merged magnetic resonance and light sheet microscopy of the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stephanie CraterPratt School of Engineering, Duke University, Durham, North Carolina, USA.
Surendra MaharjanDepartment of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
Yi QiCenter for In Vivo Microscopy, Department of Radiology, Duke University, Durham, North Carolina, USA.
Qi ZhaoCenter for In Vivo Microscopy, Department of Radiology, Duke University, Durham, North Carolina, USA.
Gary CoferCenter for In Vivo Microscopy, Department of Radiology, Duke University, Durham, North Carolina, USA.
James C CookCenter for In Vivo Microscopy, Department of Radiology, Duke University, Durham, North Carolina, USA.
G Allan JohnsonPratt School of Engineering, Duke University, Durham, North Carolina, USA; Center for In Vivo Microscopy, Department of Radiology, Duke University, Durham, North Carolina, USA.
Nian WangDepartment of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA; Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana, USA. Electronic address: nianwang@iu.edu.
Duke University · USIndiana University Health · USIndiana University – Purdue University Indianapolis · US

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Waxholm Space for Rodent NeuroinformaticsR01NS096720 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2016 to 2019
$2.4M
Characterization of Whole Brain Demyelination and Axon Damage Using High-resolution Magnetic Resonance ImagingR01NS125020 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Nian Wang · 2022 to 2026
$2.0M
Agilent Direct Drive 9.4T MRS/MRI ConsoleS10OD010683 · OD · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2012
$597k
NIBIB NIH HHS P41 EB015897NIH HHS S10 OD010683NINDS NIH HHS R01 NS096720NINDS NIH HHS R01 NS125020
6 · The paper itself

Abstract

Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and optimized to obtain high-quality, high-resolution diffusion MRI (dMRI) datasets. However, such efforts have not been fully explored in preclinical studies, especially for rodents. In this study, high quality dMRI datasets of mouse brains were acquired at 9.4T system from two vendors. In particular, we acquired a high-spatial resolution dMRI dataset (25 μm isotropic with 126 diffusion encoding directions), which we believe to be the highest spatial resolution yet obtained; and a high-angular resolution dMRI dataset (50 μm isotropic with 384 diffusion encoding directions), which we believe to be the highest angular resolution compared to the dMRI datasets at the microscopic resolution. We systematically investigated the effects of three important parameters that affect the final outcome of the connectome: b value (1000s/mm

Indexed as

ConnectomeAnimalsBrainDiffusion Magnetic Resonance ImagingHumansImage Processing, Computer-AssistedMiceConnectomeCrossing fiberDiffusion MRIHARDIHigh-resolution

Identifiers

PMID35417754
PMCPMC9195912
OpenAlexW4225291096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.