Evidence map›Paper›PMID 35417711›Full record

ArticleCell reports2022

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells.

Ann-Kathrin Reuschl, Dejan Mesner, Maitreyi Shivkumar, Matthew V X Whelan, Laura J Pallett, José Afonso Guerra-Assunção, Rajhmun Madansein, Kaylesh J Dullabh, Alex Sigal, John P Thornhill and 5 more

Abstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Manipulation of the cell cycle by HIV-1.Biochemical Society transactions · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ann-Kathrin ReuschlDivision of Infection and Immunity, University College London, London WC1E 6BT, UK. Electronic address: a.reuschl@ucl.ac.uk.
Dejan MesnerDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Maitreyi ShivkumarDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Matthew V X WhelanDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Laura J PallettDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
José Afonso Guerra-AssunçãoDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Rajhmun MadanseinDepartment of Cardiothoracic Surgery, University of KwaZulu-Natal, Durban 4091, South Africa; Centre for the AIDS Programme of Research in South Africa, Durban 4091, South Africa.
Kaylesh J DullabhDepartment of Cardiothoracic Surgery, University of KwaZulu-Natal, Durban 4091, South Africa.
Alex SigalAfrica Health Research Institute, Durban 4001, South Africa; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4091, South Africa; Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
John P ThornhillPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford OX1 3XY, UK; Department of Infectious Disease, Faculty of Medicine, Imperial College, London W2 1NY, UK.
Carolina HerreraDepartment of Infectious Disease, Faculty of Medicine, Imperial College, London W2 1NY, UK.
Sarah FidlerDepartment of Infectious Disease, Faculty of Medicine, Imperial College, London W2 1NY, UK; Imperial College NIHR Biomedical Research Centre, London W2 1NY, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Mala K MainiDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Clare JollyDivision of Infection and Immunity, University College London, London WC1E 6BT, UK. Electronic address: c.jolly@ucl.ac.uk.

Funding

Department of HealthWellcome Trust 108079/Z/15/ZWellcome Trust 223065Wellcome Trust 223065/Z/21/Z
6 · The paper itself

Abstract

HIV-1 replicates in CD4

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesHumansMemory T CellsPhenotypeVirus Replicationvpr Gene Products, Human Immunodeficiency Virusvpr Gene Products, Human Immunodeficiency Viruscell-cellCP: ImmunologyCP: MicrobiologyHIV-1permissivityresting memory T celltissue residencytranscriptional reprogrammingVpr

Identifiers

PMID35417711
PMCPMC9350556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.