Evidence map›Paper›PMID 35417710›Full record

ArticleCell reports2022

Brown adipose tissue involution associated with progressive restriction in progenitor competence.

Zan Huang, Zengdi Zhang, Zahra Moazzami, Ryan Heck, Ping Hu, Hezkiel Nanda, Kaiqun Ren, Zequn Sun, Alessandro Bartolomucci, Yan Gao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Zan HuangLaboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China; National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: huangzan@njau.edu.cn.
Zengdi ZhangDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Zahra MoazzamiDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Ryan HeckDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Ping HuDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, China.
Hezkiel NandaInstitute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Kaiqun RenDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; College of Medicine, Hunan Normal University, Changsha, Hunan 410081, China.
Zequn SunDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Alessandro BartolomucciDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Yan GaoDepartment of Human Anatomy, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Dongjun ChungDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Weiyun ZhuLaboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China; National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.
Steven ShenInstitute for Health Informatics, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Clinical Translational Science Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: hruan@umn.edu.
University of Minnesota Medical Center · USNanjing Agricultural University · CNCapital Medical University · CNHunan Normal University · CNMedical University of South Carolina · USNanjing Maternity and Child Health Care Hospital · CNThe Ohio State University · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Early Responses to Influenza A Virus Replication In VivoR01AI148669 · NIAID · UNIVERSITY OF MINNESOTA · PI LANGLOIS, RYAN · 2020 to 2024
$2.5M
Intestinal O-GlcNAc signaling and mucosal host defenseR01AI162791 · NIAID · UNIVERSITY OF MINNESOTA · PI Hai-Bin Ruan · 2022 to 2026
$2.4M
Protein O-GlcNAcylation in Regulatory T Cell FunctionR01AI139420 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2019 to 2023
$2.3M
O-GlcNAc signaling enables the intestinal epithelial remodeling associated with type 2 immunityR21AI140109 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2018 to 2019
$424k
Molecular control of BAT functions by adrenergic/purinergic signalingR56DK118150 · NIDDK · UNIVERSITY OF MINNESOTA · PI BARTOLOMUCCI, ALESSANDRO · 2019 to 2019
$385k
NCATS NIH HHS UL1 TR002494NIAID NIH HHS R01 AI139420NIAID NIH HHS R01 AI148669NIAID NIH HHS R01 AI162791NIAID NIH HHS R21 AI140109NIDDK NIH HHS R56 DK118150
6 · The paper itself

Abstract

Human brown adipose tissue (BAT) undergoes progressive involution. This involution process is not recapitulated in rodents, and the underlying mechanisms are poorly understood. Here we show that the interscapular BAT (iBAT) of rabbits whitens rapidly during early adulthood. The transcriptomic remodeling and identity switch of mature adipocytes are accompanied by loss of brown adipogenic competence of progenitors. Single-cell RNA sequencing reveals that rabbit and human iBAT progenitors highly express the FSTL1 gene. When iBAT involutes in rabbits, adipocyte progenitors reduce FSTL1 expression and are refractory to brown adipogenic recruitment. Conversely, FSTL1 is constitutively expressed in mouse iBAT to sustain WNT signaling and prevent involution. Progenitor incompetence and iBAT paucity can be induced in mice by genetic deletion of the Fstl1 gene or ablation of Fstl1

Indexed as

Adipose Tissue, BrownFollistatin-Related ProteinsAdipocytesAdipocytes, BrownAdipogenesisAnimalsHumansMiceRabbitsThermogenesisFollistatin-Related ProteinsFstl1 protein, mouseadipose progenitor cellsagingBrown adipose tissueCP: MetabolismFSTL1involutionsingle-cell RNA sequencingthermogenesisUCP1whiteningWnt signaling

Identifiers

PMID35417710
PMCPMC9664906
OpenAlexW4224083448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.