ArticleCell reports2022
Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature.Cell communication and signaling : CCS · 2026Article
- Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1.The EMBO journal · 2026Article
- Differences in Cajal-Retzius Cell Density and Postnatal Persistence Across Cortical Areas Revealed by a Novel Intersectional Genetic Labeling Approach.The Journal of comparative neurology · 2025Article
- Interneuron Diversity: How Form Becomes Function.Cold Spring Harbor perspectives in biology · 2025Review
- Development of spontaneous and sensory evoked network activity in rodent cerebral cortexFrontiers in cellular neuroscience · 2025Review
- The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.Cell reports · 2024Article
- Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing.Nature communications · 2024Article
- Article
- Review
- A Versatile Strategy for Genetic Manipulation of Cajal-Retzius Cells in the Adult Mouse Hippocampus.eNeuro · 2023Article
- Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
11 authors.
Funding
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Abstract
Cortical wiring relies on guidepost cells and activity-dependent processes that are thought to act sequentially. Here, we show that the construction of layer 1 (L1), a main site of top-down integration, is regulated by crosstalk between transient Cajal-Retzius cells (CRc) and spontaneous activity of the thalamus, a main driver of bottom-up information. While activity was known to regulate CRc migration and elimination, we found that prenatal spontaneous thalamic activity and NMDA receptors selectively control CRc early density, without affecting their demise. CRc density, in turn, regulates the distribution of upper layer interneurons and excitatory synapses, thereby drastically impairing the apical dendrite activity of output pyramidal neurons. In contrast, postnatal sensory-evoked activity had a limited impact on L1 and selectively perturbed basal dendrites synaptogenesis. Collectively, our study highlights a remarkable interplay between thalamic activity and CRc in L1 functional wiring, with major implications for our understanding of cortical development.
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