Evidence map›Paper›PMID 35417698›Full record

ArticleCell reports2022

An evolutionary gap in primate default mode network organization.

Clément M Garin, Yuki Hori, Stefan Everling, Christopher T Whitlow, Finnegan J Calabro, Beatriz Luna, Mathilda Froesel, Maëva Gacoin, Suliann Ben Hamed, Marc Dhenain and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  4. Review
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  13. A short natural history of mental time travels: a journey still travelled?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Clément M GarinDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France; Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France. Electronic address: clement.garin@vanderbilt.edu.
Yuki HoriCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada.
Stefan EverlingCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, London, ON N6A 5C1, Canada.
Christopher T WhitlowDepartment of Radiology, Section of Neuroradiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Finnegan J CalabroDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Mathilda FroeselInstitut des Sciences Cognitives Marc Jeannerod, UMR5229 CNRS Université de Lyon, 67 Boulevard Pinel, 69675 Bron Cedex, France.
Maëva GacoinInstitut des Sciences Cognitives Marc Jeannerod, UMR5229 CNRS Université de Lyon, 67 Boulevard Pinel, 69675 Bron Cedex, France.
Suliann Ben HamedInstitut des Sciences Cognitives Marc Jeannerod, UMR5229 CNRS Université de Lyon, 67 Boulevard Pinel, 69675 Bron Cedex, France.
Marc DhenainUniversité Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France; Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France.
Christos ConstantinidisDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Neuroscience Program, Vanderbilt University, Nashville, TN 37235, USA; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: christos.constantinidis.1@vanderbilt.edu.
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FRUniversity of Pittsburgh · USWestern University · CAVanderbilt University · USWake Forest University · US

Funding

Neurophysiology of Working Memory Maturation in AdolescenceR01MH116675 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS, WHITLOW, CHRISTOPHER T · 2018 to 2022
$2.4M
Neurophysiology of cognitive development and response inhibitionR01MH117996 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS · 2018 to 2022
$2.1M
NIMH NIH HHS R01 MH116675NIMH NIH HHS R01 MH117996
6 · The paper itself

Abstract

The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate's DMN and its associated cognitive functions.

Indexed as

BrainBrain MappingAnimalsCallithrixDefault Mode NetworkMagnetic Resonance ImagingNeural PathwaysBOLDCP: NeuroscienceDMNevolutionfMRImacaquemarmosetmedial prefrontal cortexmouse lemurprimatesresting-state

Identifiers

PMID35417698
PMCPMC9088817
OpenAlexW4226167020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.