Evidence map›Paper›PMID 35417692›Full record

ArticleCell reports2022

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands.

Olivier Mauduit, Marit H Aure, Vanessa Delcroix, Liana Basova, Amrita Srivastava, Takeshi Umazume, Jacqueline W Mays, Saverio Bellusci, Abigail S Tucker, Mohammad K Hajihosseini and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Ascl3The Journal of physiology · 2026
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  13. Neuronal and hormonal control of CaThe Journal of physiology · 2024
    Review
  14. Article
  15. A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  16. Article
  17. Article
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  19. Article
  20. Acquired CFTR dysfunction and dense distribution of ionocytes in nasal mucosa of children with CRS.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Olivier MauduitDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Marit H AureMatrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Vanessa DelcroixDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liana BasovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Amrita SrivastavaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Takeshi UmazumeDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jacqueline W MaysOral Immunobiology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Saverio BellusciCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), The German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giessen, Germany.
Abigail S TuckerCentre for Craniofacial and Regenerative Biology, King's College London, London WC2R 2LS, UK.
Mohammad K HajihosseiniSchool of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Matthew P HoffmanMatrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: mhoffman@nih.gov.
Helen P MakarenkovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: hmakarenk@scripps.edu.
Scripps Research Institute · USNational Institutes of Health · USJustus-Liebig-Universität Gießen · DEKing's College London · GBUniversity of East Anglia · GB

Funding

Immunobiology and therapy of oral mucosal and salivary gland chronic graft-versus-host diseaseZIADE000747 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2016 to 2025
$14.9M
Progenitor/Stem Cell Function During Salivary Gland DevelopmentZIADE000722 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$13.7M
Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Salivary gland ionocyte organization and function during homeostasis, repair, and diseaseR01DE031044 · NIDCR · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2021 to 2025
$3.0M
FGF signaling in lacrimal gland homeostasis, regeneration and diseaseR01EY028983 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2018 to 2020
$1.4M
NEI NIH HHS R01 EY026202NEI NIH HHS R01 EY028983NIDCR NIH HHS R01 DE031044
6 · The paper itself

Abstract

Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived growth factor and a critical regulator of fetal organ development in mice and humans. Using a single-cell RNA sequencing (RNA-seq) atlas of salivary gland (SG) and a tamoxifen inducible Fgf10

Indexed as

Fibroblast Growth Factor 10Receptor, Fibroblast Growth Factor, Type 2Salivary GlandsAnimalsEpithelial CellsForkhead Transcription FactorsMiceSignal TransductionFgf10 protein, mouseFibroblast Growth Factor 10Forkhead Transcription FactorsFoxi1 protein, mouseReceptor, Fibroblast Growth Factor, Type 2CFTRCP: Developmental biologyduct cellsFGF10FGFR2b signalingFoxi1ionocytesniche cellssalivary glandsingle-cell RNA sequencingsubmandibular gland

Identifiers

PMID35417692
PMCPMC9113928
OpenAlexW4224061801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.