ArticleCell reports2022
Dopamine and serotonin interplay for valence-based spatial learning.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.Hippocampus · 2026Article
- Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment.Human brain mapping · 2026Article
- Dopamine modulation of spike-timing-dependent plasticity for spatio-temporal spike pattern detection in single neurons.Frontiers in computational neuroscience · 2026Article
- PMAT enhances sexual dimorphism of fear behaviors and facilitates female mice's generalized contextual fear extinction.Frontiers in neuroscience · 2026Article
- Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.eLife · 2025Article
- Neurodevelopmental toxicity and mechanism of chlorinated polyfluoroalkyl ether sulfonate alternative F-53B in pubertal male rats.Archives of toxicology · 2025Article
- Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.Cell reports · 2025Article
- Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.Frontiers in neuroscience · 2025Review
- Astrocytes enhance plasticity response during reversal learning.Communications biology · 2024Article
- Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Article
- Projections from the Prefrontal Cortex to Zona Incerta Mediate Fear Generalization.Neuroscience bulletin · 2023Article
- Navigating Like a Fly:International journal of molecular sciences · 2023Review
- Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance.Psychological medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Dopamine (DA) and serotonin (5-HT) are important neuromodulators of synaptic plasticity that have been linked to learning from positive or negative outcomes or valence-based learning. In the hippocampus, both affect long-term plasticity but play different roles in encoding uncertainty or predicted reward. DA has been related to positive valence, from reward consumption or avoidance behavior, and 5-HT to aversive encoding. We propose DA produces overall LTP while 5-HT elicits LTD. Here, we compare two reward-modulated spike timing-dependent plasticity (R-STDP) rules to describe the action of these neuromodulators. We examined their role in cognitive performance and flexibility for computational models of the Morris water maze task and reversal learning. Our results show that the interplay of DA and 5-HT improves learning performance and can explain experimental evidence. This study reinforces the importance of neuromodulation in determining the direction of plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.