ArticleArquivos brasileiros de oftalmologia
Assessments of the ocular surface and meibomian gland morphology in patients with treatment-naive acne vulgaris.
Article in Arquivos brasileiros de oftalmologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin.Life (Basel, Switzerland) · 2026Review
- Anterior segment optical coherence tomography study of the cornea and tear film after systemic isotretinoin treatment in acne vulgaris.BMC ophthalmology · 2025Observational
- Ocular surface changes in moderate-to-severe acne vulgaris.International journal of ophthalmology · 2024Article
- A review on drug-induced dry eye disease.Indian journal of ophthalmology · 2023Review
- Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2023Review
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2 authors at 1 institution in 1 country.
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Abstract
purposeTo investigate ocular surface and meibomian glands in patients with treatment-naive acne vulgaris.
methodsThe Ocular Surface Disease Index (OSDI) questionnaire, invasive tear film breakup time, fluorescein staining of the ocular surface, and Schirmer II test were performed for all subjects. Total eyelid and meibomian gland secretion scores were assessed. Non-contact meibography was performed with the Sirius corneal topographic device.
resultsThe right eyes of 35 patients with acne vulgaris and 35 healthy volunteers were included the study. While the OSDI and staining scores were significantly higher in the acne group than in the control group (p=0.01 and p=0.003, respectively), the invasive tear film breakup time and Schirmer measurements were significantly lower in the acne group (p=0.000 and p=0.003, respectively). The total eyelid and meibomian gland secretion scores were also higher in the acne group than in the control group (p=0.003 and p=0.000, respectively). On the morphological evaluation of the meibomian glands, the thickening, thinning, tortuosity, and presence of ghost areas were statistically significantly more common in the acne vulgaris group than in the control group (p=0.000, p=0.001, p=0.05, and p=0.006, respectively). The percentage of the meibomian gland loss area was significantly high in the acne vulgaris group on both upper and lower meibography. The meibomian gland loss area positively correlated with total eyelid and meibomian gland secretion scores.
conclusionAcne vulgaris may have a predisposition to meibomian gland dysfunction and ocular surface damage. Early recognition of meibomian gland and ocular surface alterations seems important, especially in acne vulgaris cases for which oral isotretinoin treatment is planned.
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