ArticlePloS one2022
The effect of metabolic health and obesity on lung function: A cross sectional study of 114,143 participants from Kangbuk Samsung Health Study.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 7 citations in OpenAlex.
- Beyond the Threshold: Nonlinear Impact of Body Mass Index on Pulmonary Function in Severe Obesity.Obesity facts · 2026Article
- Subclinical Respiratory Impairment and Quality of Life Among Non-Smoking Adults in Rural Chiang Mai, Thailand.Journal of clinical medicine · 2026Article
- The age- and sex-specific association between metabolic body composition and lung function: a cross-sectional study.Endocrine journal · 2026Observational
- Effects of metabolic syndrome and its components on pulmonary function and functional capacity in children and adolescents with obesity.European journal of pediatrics · 2025Article
- Metabolic Health, Overweight or Obesity, and Lung Function in Older Australian Adults.Nutrients · 2024Article
- Metabolically healthy and unhealthy obesity and the development of lung dysfunction.Scientific reports · 2023Article
- Body mass index affects spirometry indices in patients with chronic obstructive pulmonary disease and asthma.Frontiers in physiology · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
objectiveAlthough the role of obesity-induced metabolic abnormalities in impaired lung function is well-established, the risk of impaired lung function among obese individuals without metabolic abnormalities, referred to metabolically-healthy obesity (MHO), is largely unexplored. Therefore, we evaluated the impact of MHO on lung function in a large health-screening cohort.
methods114,143 subjects (65,342 men, mean age and BMI: 39.6 years and 23.6) with health examinations in 2019 were divided into four groups as follows: metabolically healthy non-obese (MHNO), MHO, metabolically unhealthy non-obese (MUHNO), and metabolically unhealthy obese (MUHO). Metabolic health was defined as fewer than two metabolic syndrome components. Obesity was defined as BMI ≥25 kg/m2. Adjusted odds ratios (aORs), using MHNO as a reference, were calculated to determine lung function impairment.
resultsApproximately one-third (30.6%) of the study subjects were obese. The prevalence of MHO was 15.1%. Subjects with MHO had the highest FEV1% and FVC% values but the lowest FEV1/FVC ratio (p<0.001). These results persisted after controlling for covariates. Compared with MHNO, the aORs (95% confidence interval) for FEV1% < 80% in MHO, MUHNO and MUHO were 0.871 (0.775-0.978), 1.274 (1.114-1.456), and 1.176 (1.102-1.366), respectively (P for trend = 0.014). Similarly, the aORs in MHO, MUHNO, and MUHO were 0.704 (0.615-0.805), 1.241 (1.075-1.432), and 1.226 (1.043-1.441), respectively, for FVC% < 80% (p for trend = 0.013). However, the aORs for FEV1/FVC<0.7 were not significantly different between groups (p for trend = 0.173).
conclusionsThe MHO group had better lung function than other groups. However, longitudinal follow-up studies are required to validate our findings.
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