Evidence map›Paper›PMID 35417201›Full record

ArticleScience robotics2022

Telerobotic neurovascular interventions with magnetic manipulation.

Yoonho Kim, Emily Genevriere, Pablo Harker, Jaehun Choe, Marcin Balicki, Robert W Regenhardt, Justin E Vranic, Adam A Dmytriw, Aman B Patel, Xuanhe Zhao

Open access · greenAbstract read
In one paragraph

Article in Science robotics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
27.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 357 citations in OpenAlex.

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  18. Initial clinical experience with the Bendit steerable articulating tip microcatheter for intracranial access and intervention.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yoonho KimDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-3677-7738
Emily GenevriereDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Pablo HarkerDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0263-8748
Jaehun ChoeDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-3444-4219
Marcin BalickiPhilips Research North America, Cambridge, MA, USA.ORCID 0000-0003-4340-6222
Robert W RegenhardtDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2958-3484
Justin E VranicDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6000-6709
Adam A DmytriwDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0131-5699
Aman B PatelDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Xuanhe ZhaoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-5387-6186
Harvard University · USMassachusetts Institute of Technology · USPhilips (United States) · US

Funding

Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
NHLBI NIH HHS R01 HL153857
6 · The paper itself

Abstract

Advances in robotic technology have been adopted in various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision and accuracy with reduced fatigue of the surgeon. Despite the advantages, robotic applications to endovascular neurosurgery have remained largely unexplored because of technical challenges such as the miniaturization of robotic devices that can reach the complex and tortuous vasculature of the brain. Although some commercial systems enable robotic manipulation of conventional guidewires for coronary and peripheral vascular interventions, they remain unsuited for neurovascular applications because of the considerably smaller and more tortuous anatomy of cerebral arteries. Here, we present a teleoperated robotic neurointerventional platform based on magnetic manipulation. Our system consists of a magnetically controlled guidewire, a robot arm with an actuating magnet to steer the guidewire, a set of motorized linear drives to advance or retract the guidewire and a microcatheter, and a remote-control console to operate the system under real-time fluoroscopy. We demonstrate our system's capability to navigate narrow and winding pathways both in vitro with realistic neurovascular phantoms representing the human anatomy and in vivo in the porcine brachial artery with accentuated tortuosity for preclinical evaluation. We further demonstrate telerobotically assisted therapeutic procedures including coil embolization and clot retrieval thrombectomy for treating cerebral aneurysms and ischemic stroke, respectively. Our system could enable safer and quicker access to hard-to-reach lesions while minimizing the radiation exposure to physicians and open the possibility of remote procedural services to address challenges in current stroke systems of care.

Indexed as

Endovascular ProceduresIntracranial AneurysmRoboticsRobotic Surgical ProceduresAnimalsMagnetic PhenomenaSwine

Identifiers

PMID35417201
PMCPMC9254892
OpenAlexW4223931121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.