Evidence map›Paper›PMID 35417187›Full record

ArticleScience translational medicine2022

NK cells limit therapeutic vaccine-induced CD8

Mariana O Diniz, Anna Schurich, Senthil K Chinnakannan, Marion Duriez, Kerstin A Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E Amin, Frances Alcock and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  3. Article
  4. Article
  5. The role of PD‑1/PD‑L1 axis in liver diseases.Clinical and experimental medicine · 2025
    Review
  6. Review
  7. HBV Suppression by Nucleos(t)ide Analogues Reduces PD-1 Expression on Liver-Resident T Cells.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. KIR-HLA interactions extend human CD8+ T cell lifespan in vivo.The Journal of clinical investigation · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mariana O DinizDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0002-1961-0189
Anna SchurichDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0002-2525-3114
Senthil K ChinnakannanPeter Medawar Building for Pathogen Research, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
Marion DuriezDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.
Kerstin A StegmannDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.
Jessica DaviesDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.
Stephanie KucykowiczDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0002-8849-218X
Kornelija SuveizdyteDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0001-8235-0431
Oliver E AminDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0003-3663-1253
Frances AlcockDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.
Tamsin CargillPeter Medawar Building for Pathogen Research, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2863-0835
Eleanor BarnesPeter Medawar Building for Pathogen Research, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-0860-0831
Mala K MainiDivision of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK.ORCID 0000-0001-6384-1462
Centre for Immunity, Infection and Evolution · GBUniversity of Oxford · GB

Funding

Cancer Research UK 26603Cancer Research UK 26813Department of HealthMedical Research Council G0901374Wellcome TrustWellcome Trust 211042/Z/18/ZWellcome Trust 214191/Z/18/Z
6 · The paper itself

Abstract

A better understanding of mechanisms that regulate CD8

Indexed as

B7-H1 AntigenVaccinesAnimalsCD8-Positive T-LymphocytesCytokinesKiller Cells, NaturalMiceProgrammed Cell Death 1 ReceptorB7-H1 AntigenCytokinesProgrammed Cell Death 1 ReceptorVaccines

Identifiers

PMID35417187
PMCPMC7619356
OpenAlexW4223889036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.