Evidence map›Paper›PMID 35417039›Full record

ArticleActa psychiatrica Scandinavica2022

Scalability of the Positive and Negative Syndrome Scale in first-episode schizophrenia assessed by Rasch models.

Lone Baandrup, Peter Allerup, Mette Ø Nielsen, Signe W Düring, Kirsten B Bojesen, Stefan Leucht, Silvana Galderisi, Armida Mucci, Paola Bucci, Celso Arango and 8 more

Abstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Lone BaandrupCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.ORCID 0000-0003-1662-2720
Peter AllerupAarhus University, Copenhagen, Denmark.
Mette Ø NielsenCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.ORCID 0000-0002-0780-7099
Signe W DüringCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.ORCID 0000-0002-6589-3116
Kirsten B BojesenCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Stefan LeuchtDepartment of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, München, Germany.
Silvana GalderisiDepartment of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
Armida MucciDepartment of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
Paola BucciDepartment of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID 0000-0001-9027-1047
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID 0000-0001-8538-3175
Paola DazzanNational Institute for Health Research Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
Philip McGuireNational Institute for Health Research Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
Arsime DemjahaNational Institute for Health Research Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
Bjørn H EbdrupCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Wolfgang W FleischhackerDepartment of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Medical University Innsbruck, Innsbruck, Austria.
René S KahnDepartment of Psychiatry, Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Birte Y GlenthøjCenter for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.

Funding

Medical Research Council MC_PC_11003Medical Research Council MR/S003444/1
6 · The paper itself

Abstract

objectiveHistorically, assessment of the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) has had several foci: (1) calculation of reliability indexes, (2) extraction of subdimensions from the scale, and (3) assessment of the validity of the total score. In this study, we aimed to examine the scalability and to assess the clinical performance of the 30-item PANSS total score as well as the scalability of a shorter version (PANSS-6) of the scale.

methodsA composite data set of 1073 patients with first-episode schizophrenia or schizophrenia spectrum disorder was subjected to Rasch analysis of PANSS data from baseline and 4-6 weeks follow-up.

resultsThe central tests of fit of the Rasch model failed to satisfy the statistical requirements behind item homogeneity for the PANSS-30 as well as the PANSS-6 total score. For the PANSS-30, Differential Item Functioning was pronounced both for the 7-point Likert scale rating categories and when dichotomizing the rating categories. Subsequently, the Rasch structure analysis in the context of dichotomized items was used to isolate and estimate a systematic error because of item inhomogeneity, as well as a random error. The size of the combined sources of error for the PANSS-30 total score approximated 20% which is often regarded as clinical cut-off between response versus no-response.

conclusionThe results demonstrate the operational consequences of a lack of statistical fit of the Rasch model and suggest that the calculated measure of uncertainty needs to be considered when using the PANSS-30 total score.

Indexed as

SchizophreniaHumansPsychometricsReproducibility of Resultsfirst-episodeitem response theoryRasch analysisrating scaleschizophrenia

Identifiers

PMID35417039
PMCPMC9325503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.