Evidence map›Paper›PMID 35417035›Full record

ArticleOncology reports2022

Blue light irradiation inhibits the growth of colon cancer and activation of cancer‑associated fibroblasts.

Toshiaki Yoshimoto, Mitsuo Shimada, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuma Wada, Shohei Okikawa, Kozo Yoshikawa

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Blue LED photobiomodulation in the prevention of radiodermatitis in breast cancer survivors: a clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  2. Review
  3. Review
  4. Article
  5. Base-Catalyzed Pathway Towards Isocyanate Derivatives of Silsesquioxanes.International journal of molecular sciences · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Toshiaki YoshimotoDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Mitsuo ShimadaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Takuya TokunagaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Toshihiro NakaoDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Masaaki NishiDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Chie TakasuDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Hideya KashiharaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Yuma WadaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Shohei OkikawaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Kozo YoshikawaDepartment of Surgery, Tokushima University Graduate School, Tokushima 770‑8503, Japan.
Tokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irradiation with a specific wavelength of light using light‑emitting diodes (LEDs) has various effects on cells and organisms. Recently, the antitumor effects of visible blue light on tumor cells were reported; however, the mechanism and effects on the tumor microenvironment remain unclear. Human colon cancer cells (HCT‑116) were injected into the rectal wall of nude mice. Tumors were irradiated with a 465‑nm LED light at 30 mW/cm

Indexed as

Cancer-Associated FibroblastsColonic NeoplasmsLightAnimalsB7-H1 AntigenCell MovementCell ProliferationHCT116 CellsHumansMiceMice, NudeRod OpsinsTumor MicroenvironmentB7-H1 AntigenOPN3 protein, humanOPN3 protein, mouseRod Opsinsblue light‑emitting diodecancer‑associated fibroblastscolorectal cancerin vivoopsin 3

Identifiers

PMID35417035
PMCPMC9019302
OpenAlexW4223445880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.