SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Comparable treatment response rates with benzathine penicillin and doxycycline in early syphilis: evidence from a large German cohort.Infection · 2026Article
- A distinct IgM immunoblot signature differentiates neurosyphilis from latent syphilis.Microbiology spectrum · 2026Article
- Analysis of the spatio-temporal pattern and evolutionary trends of syphilis at township level in Xining City, Qinghai Province, China from 2008 to 2024.Scientific reports · 2026Article
- Meningovascular Neurosyphilis Presenting as Multifocal Stroke: A Case Report and Literature Review.Cureus · 2026Article
- White Matter Integrity in General Paresis: An Exploratory Tract-Based Spatial Statistical Analysis.Neuropsychiatric disease and treatment · 2026Article
- Concurrent hepatitis and anterior uveitis in an immunocompetent patient with secondary syphilis: A case report.Medicine · 2025Article
- Serofast state after syphilis treatment: implications and recommendations for clinical practice. Narrative review.Postepy dermatologii i alergologii · 2025Review
- Analysis of Factors Determining Serologic Response to Treatment of Early Syphilis in Adult Men.Infectious disease reports · 2025Article
- Unraveling the resurgence of syphilis: a deep dive into the epidemic sweeping across the United States; a mini review.Annals of medicine and surgery (2012) · 2025Review
- Research progress on the mechanisms of neurosyphilis' impact on cognitive function, early identification, and prevention strategies.Frontiers in neurology · 2025Review
- Research Advances in Clinical Strategies and Preclinical Models for Syphilis Relapse.Infection and drug resistance · 2025Review
- Early neurosyphilis with serofast state.Emerging microbes & infections · 2024Article
- Sexually Transmitted Infections in People with Human Immunodeficiency Virus.Infectious disease clinics of North America · 2024Review
- Syphilis Clinical Complexity: A Dual-Case Study Illustrating Diagnostic Dilemmas and Management Strategies.Cureus · 2024Article
- Clinical and laboratory features of neurosyphilis: A single-center, retrospective study of 402 patients.Heliyon · 2024Article
- Comparison of the Accuracy of HSV1 and HSV2 Antibody Tests with PCR in the Diagnosis of Recurrent Genital Herpes.Clinical, cosmetic and investigational dermatology · 2024Article
- Syphilitic uveitis in HIV-positive patients: report of a case series, treatment outcomes, and comprehensive review of the literature.International journal of ophthalmology · 2023Article
- Syphilis Infections, Reinfections and Serological Response in a Large Italian Sexually Transmitted Disease Centre: A Monocentric Retrospective Study.Journal of clinical medicine · 2022Article
- A Case Report of Secondary Syphilis Co-Infected with Measles: A Diagnostic Dilemma with Fever and Rash.Tropical medicine and infectious disease · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A panel of experts generated 5 "key questions" in the management of adult syphilis. A systematic literature review was conducted and tables of evidence were constructed to answer these questions. Available data suggest no clinical benefit to >1 dose of benzathine penicillin G for early syphilis in human immunodeficiency virus (HIV)-infected patients. While penicillin remains the drug of choice to treat syphilis, doxycycline to treat early and late latent syphilis is an acceptable alternate option if penicillin cannot be used. There are very limited data regarding the impact of additional antibiotic doses on serologic responses in serofast patients and no data on the impact of additional antibiotic courses on long-term clinical outcomes. In patients with isolated ocular or otic signs and symptoms, reactive syphilis serologic results, and confirmed ocular/otic abnormalities at examination, a diagnostic cerebrospinal fluid (CSF) examination is not necessary, because up to 40% and 90% of patients, respectively, would have no CSF abnormalities. Based on the results of 2 studies, repeated CSF examinations are not necessary for HIV-uninfected patients or HIV-infected patients on antiretroviral therapy who exhibit appropriate serologic and clinical responses after treatment for neurosyphilis. Finally, several important gaps were identified and should be a priority for future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.