Evidence map›Paper›PMID 35416709›Full record

ArticleAntimicrobial agents and chemotherapy2022

Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance.

Yawei Du, Carlo Giannangelo, Wei He, Gerald J Shami, Wenya Zhou, Tuo Yang, Darren J Creek, Con Dogovski, Xinsong Li, Leann Tilley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yawei DuDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.
Carlo GiannangeloDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, Victoria, Australia.
Wei HeSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Gerald J ShamiDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.
Wenya ZhouSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Tuo YangDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.
Darren J CreekDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, Victoria, Australia.ORCID 0000-0001-7497-7082
Con DogovskiDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.
Xinsong Li *School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Leann Tilley *Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbournegrid.1008.9, Parkville, Victoria, Australia.ORCID 0000-0001-9910-0199
The University of Melbourne · AUSoutheast University · CNMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current best practice for the treatment of malaria relies on short half-life artemisinins that are failing against emerging Kelch 13 mutant parasite strains. Here, we introduce a liposome-like self-assembly of a dimeric artesunate glycerophosphocholine conjugate (dAPC-S) as an amphiphilic prodrug for the short-lived antimalarial drug, dihydroartemisinin (DHA), with enhanced killing of Kelch 13 mutant artemisinin-resistant parasites. Cryo-electron microscopy (cryoEM) images and the dynamic light scattering (DLS) technique show that dAPC-S typically exhibits a multilamellar liposomal structure with a size distribution similar to that of the liposomes generated using thin-film dispersion (dAPC-L). Liquid chromatography-mass spectrometry (LCMS) was used to monitor the release of DHA. Sustainable release of DHA from dAPC-S and dAPC-L assemblies increased the effective dose and thus efficacy against Kelch 13 mutant artemisinin-resistant parasites in an

Indexed as

AntimalarialsArtemisininsMalariaMalaria, FalciparumArtesunateCryoelectron MicroscopyDrug ResistanceHumansLiposomesPlasmodium falciparumAntimalarialsartemisininArtemisininsArtesunateLiposomesartemisininglycerophosphocholinemalariananoparticlesplasmodium

Identifiers

PMID35416709
PMCPMC9112877
OpenAlexW4223540885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.