Evidence map›Paper›PMID 35416701›Full record

ArticleMicrobiology spectrum2022

Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections.

Francesca Sivori, Ilaria Cavallo, Daniela Kovacs, Maria Guembe, Isabella Sperduti, Mauro Truglio, Martina Pasqua, Grazia Prignano, Arianna Mastrofrancesco, Luigi Toma and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. The AcrAB efflux pump contributes to the virulence of EnteroaggregativeFrontiers in cellular and infection microbiology · 2025
    Article
  4. Genomic characterization and antibiotic susceptibility of biofilm-formingFrontiers in cellular and infection microbiology · 2025
    Article
  5. Biofilm · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Antimicrobial Treatment ofAntibiotics (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Francesca SivoriMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Ilaria CavalloMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Daniela KovacsCutaneous Physiopathology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Maria GuembeDepartment of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañóngrid.410526.4, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.ORCID 0000-0002-7607-5848
Isabella SperdutiBiostatistical Unit-Clinical Trials Center, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Mauro TruglioCutaneous Physiopathology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Martina PasquaDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, Rome, Italy.
Grazia PrignanoMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Arianna MastrofrancescoMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Luigi TomaDepartment of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Fulvia PimpinelliMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Aldo MorroneScientific Direction, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Fabrizio EnsoliMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.
Enea Gino Di DomenicoMicrobiology and Virology, IRCCS San Gallicano Dermatological Institute, Rome, Italy.ORCID 0000-0001-6295-6006
San Gallicano Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITHospital General Universitario Gregorio Marañón · ESSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has become the leading cause of skin and soft tissue infections (SSTIs). Biofilm production further complicates patient treatment, contributing to increased bacterial persistence and antibiotic tolerance. The study aimed to explore the efficacy of different antibiotics on biofilm-producing MRSA isolated from patients with SSTI. A total of 32 MRSA strains were collected from patients with SSTI. The MIC and minimal biofilm eradication concentration (MBEC) were measured in planktonic and biofilm growth. The study showed that dalbavancin, linezolid, and vancomycin all inhibited MRSA growth at their EUCAST susceptible breakpoint. Of the MRSA strains, 87.5% (

Indexed as

Methicillin-Resistant Staphylococcus aureusSoft Tissue InfectionsStaphylococcal InfectionsAnti-Bacterial AgentsBiofilmsDNAHumansLinezolidMicrobial Sensitivity TestsStaphylococcus aureusTeicoplaninVancomycinAnti-Bacterial AgentsdalbavancinDNALinezolidTeicoplaninVancomycinbiofilmdalbavancinextracellular DNAMRSAStaphylococcus aureus

Identifiers

PMID35416701
PMCPMC9045124
OpenAlexW4223601557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.