Evidence map›Paper›PMID 35416698›Full record

ArticleMicrobiology spectrum2022

Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.

Na Pei, Yanming Li, Chunjiao Liu, Zijuan Jian, Tianzhu Liang, Yiming Zhong, Wanying Sun, Jingxuan He, Xinyi Cheng, Hongling Li and 9 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  9. Antibiotic resistance and novel Sequence Types ofCurrent research in microbial sciences · 2025
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  10. CombatingFrontiers in cellular and infection microbiology · 2025
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  15. Comparative Genomics Revealing the Genomic Characteristics ofTropical medicine and infectious disease · 2024
    Article
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  18. Outer Membrane Vesicles TransmittingAntimicrobial agents and chemotherapy · 2023
    Article
  19. Article
  20. Genome-wide association study ofFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Na Pei *BGI-Shenzhen, Shenzhen, Guangdong, China.ORCID 0000-0003-4156-1130
Yanming Li *Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunjiao Liu *BGI-Shenzhen, Shenzhen, Guangdong, China.ORCID 0000-0003-3913-1887
Zijuan Jian *Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tianzhu Liang *BGI-Shenzhen, Shenzhen, Guangdong, China.
Yiming Zhong *Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wanying SunBGI-Shenzhen, Shenzhen, Guangdong, China.
Jingxuan HeDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xinyi ChengBGI-Shenzhen, Shenzhen, Guangdong, China.
Hongling LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaole LeiBGI-Shenzhen, Shenzhen, Guangdong, China.
Xin LiuBGI-Shenzhen, Shenzhen, Guangdong, China.
Ziqing DengBGI-Shenzhen, Shenzhen, Guangdong, China.
Qingxia LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xia ChenDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qun YanDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Karsten KristiansenBGI-Shenzhen, Shenzhen, Guangdong, China.
Junhua LiBGI-Shenzhen, Shenzhen, Guangdong, China.
Wenen LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0003-2561-1118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global dissemination of K. pneumoniae clones poses health hazards to the public. Genomic epidemiology studies with comprehensive data set further revealed clone divergence, showing a high complexity in evolution. Moreover, clones carrying both acquired virulent and antimicrobial-resistant genes emerged and might replace the carbapenem-resistant clones. Co-occurrence of virulence and resistance is emerging. An unbiased collection of 3,061 clinical K. pneumoniae isolates (January 5, 2013 to July 24, 2018) underwent whole-genome sequencing. Pairwise core-genome single-nucleotide polymorphism (cgSNP) distances identified clone divergence and transmission events. A sum of 2,193 nonduplicated genomes clustered into four phenotypically indistinguishable species complexes. 93% (

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial Agentsbeta-LactamasesClone CellsDrug Resistance, Multiple, BacterialGenomicsHumansInfant, NewbornMicrobial Sensitivity TestsPhylogenyAnti-Bacterial Agentsbeta-Lactamasesclone divergencegenomic epidemiologyKlebsiella pneumoniaenosocomial transmission

Identifiers

PMID35416698
PMCPMC9045374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.