Evidence map›Paper›PMID 35416537›Full record

ArticleActa diabetologica2022

Effectiveness of adding alarms to flash glucose monitoring in adults with type 1 diabetes under routine care.

Federico Boscari, Sara Ferretto, Francesco Cavallin, Gian Paolo Fadini, Angelo Avogaro, Daniela Bruttomesso

Open access · hybridAbstract read
In one paragraph

Article in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Impact of the FreeStyle Libre 2Diagnostics (Basel, Switzerland) · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Federico BoscariDepartment of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Sara FerrettoDivision of Metabolic Diseases, University Hospital of Padova, 36020, Solagna, Italy.
Francesco CavallinIndependent Statistician, 36020, Solagna, Italy.
Gian Paolo FadiniDepartment of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Angelo AvogaroDepartment of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Daniela BruttomessoDepartment of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padova, Italy. daniela.bruttomesso@unipd.it.ORCID http://orcid.org/0000-0002-2426-8955
University of Padua · ITIstituto Nazionale di Statistica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWhether glucose sensor alarms improve metabolic control and are accepted by individuals with diabetes is unclear. Here, we investigated whether switching from a standard flash glucose monitoring system (FGM1) to a system equipped with hypo- and hyperglycemia alarms (FGM2) improves glycemic control and psychological outcomes in adults with type 1 diabetes (T1D).

methodsSubjects with T1D and > 4% of time in hypoglycemia or > 40% of time in hyperglycemia were studied while wearing FGM1 (4 weeks) and after switching to FGM2 for 8 weeks. The primary endpoint was the change in time in range (TIR 70-180 mg/dl [3.9-10.0 mmol/L]) after 4 weeks of FGM2 use. Time below range (TBR), time above range (TAR), mean glucose, coefficient of variation (CV), sensor scans, treatment satisfaction, and hypoglycemia fear were secondary outcomes.

resultsWe included 38 subjects aged 33.7 ± 12.6 year. During 4 weeks of FGM2 use, TIR increased from 52.8 to 57.0% (p = 0.001), TBR decreased from 6.2 to 3.4% (p < 0.0001) as did time < 54 mg/dl (from 1.4 to 0.3%, p < 0.0001) and CV (from 39.6% to 36.1%, p < 0.0001). These changes were confirmed after 8 weeks of FGM2 use. Treatment satisfaction improved and fear of hypoglycemia decreased. Subjects who had > 4% of time in hypoglycemia at baseline showed the greatest improvements in glucose control and treatment satisfaction.

conclusionSwitching from FGM1 to FGM2 improved TIR and treatment satisfaction and reduced fear of hypoglycemia. Participants who benefited most from switching from FGM1 to FGM2 were those prone to hypoglycemia.

Indexed as

Diabetes Mellitus, Type 1HyperglycemiaHypoglycemiaAdultBlood GlucoseBlood Glucose Self-MonitoringHumansHypoglycemic AgentsInsulinBlood GlucoseHypoglycemic AgentsInsulinFlash glucose monitoring-Free Style Libre 1 and 2Glucose controlPsychological aspectsTime in rangeType 1 diabetes

Identifiers

PMID35416537
PMCPMC9156464
OpenAlexW4223465053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.