Evidence map›Paper›PMID 35416487›Full record

ArticleApplied microbiology and biotechnology2022

Mutants lacking global regulators, fis and arcA, in Escherichia coli enhanced growth fitness under acetate metabolism by pathway reprogramming.

Shikha Jindal, Mahesh S Iyer, Poonam Jyoti, Shyam Kumar Masakapalli, K V Venkatesh

Abstract read
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In one paragraph

Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Antimicrobial resistance and mechanisms of epigenetic regulation.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shikha JindalDepartment of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Mahesh S IyerDepartment of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Poonam JyotiBioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, 175075, India.
Shyam Kumar MasakapalliBioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, 175075, India. shyam@iitmandi.ac.in.
K V VenkateshDepartment of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India. venks@iitb.ac.in.
Indian Institute of Technology Bombay · INIndian Institute of Technology Mandi · IN

Funding

department of biotechnology , ministry of science and technology BT/PF13713/BBE/117/83/2015indian institute of technology mandi IITM/SG/SKM/48
6 · The paper itself

Abstract

Global regulatory transcription factors play a significant role in controlling microbial metabolism under genetic and environmental perturbations. A system-level effect of carbon sources such as acetate on microbial metabolism under disrupted global regulators has not been well established. Acetate is one of the major substrates available in various nutrient niches such as the mammalian gut and a keto diet. A substantial amount of acetate gets secreted in aerobic metabolism. Therefore, investigating the study on acetate metabolism is highly significant. It is known that the global regulators fis and arcA regulate acetate uptake genes in E. coli under glucose conditions. This study deciphered the growth and flux distribution of E. coli transcription regulatory knockouts Δfis, ΔarcA and double deletion mutant, ΔarcAΔfis under acetate using

Indexed as

Escherichia coliEscherichia coli ProteinsBacterial Outer Membrane ProteinsCarbonCitric Acid CycleFactor For Inversion Stimulation ProteinGene Expression Regulation, BacterialRepressor ProteinsarcA protein, E coliBacterial Outer Membrane ProteinsCarbonEscherichia coli ProteinsFactor For Inversion Stimulation ProteinFis protein, E coliRepressor Proteins13C-metabolic flux analysisAcetate metabolismEscherichia coliGlobal regulators

Identifiers

PMID35416487
OpenAlexW4223617529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.