SynthesisReviews in medical virology2022
Baseline physical activity is associated with reduced mortality and disease outcomes in COVID-19: A systematic review and meta-analysis.
Synthesis in Reviews in medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Beverage consumption on bone and joint disorders: an umbrella review.Journal of global health · 2025Pooled it
- Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation.Molecular neurobiology · 2023Pooled it
- The effect of adherence to high-quality dietary pattern on COVID-19 outcomes: A systematic review and meta-analysis.Journal of medical virology · 2023Pooled it
- Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis.BMC medicine · 2022Pooled it
- The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis.Journal of medical virology · 2022Pooled it
- Baseline physical activity is associated with reduced mortality and disease outcomes in COVID-19: A systematic review and meta-analysis.Reviews in medical virology · 2022Pooled it
- SARS-CoV-2 Pneumonia: Advances in Diagnosis and Treatment.Microorganisms · 2025Review
- COVID-19 Vaccine Effectiveness and Risk Factors of Booster Failure in 480,000 Patients with Diabetes Mellitus: A Population-Based Cohort Study.Microorganisms · 2025Article
- Management of SARS-CoV-2 Infection-Clinical Practice Guidelines of the Polish Association of Epidemiologists and Infectiologists, for 2025.Journal of clinical medicine · 2025Review
- Impact of coronavirus (COVID-19) pandemic on physical activity levels in different sub-populations of Iranians: a national survey.Scientific reports · 2025Article
- Association of Pulmonary Involvement at Baseline with Exercise Intolerance and Worse Physical Functioning 8 Months Following COVID-19 Pneumonia.Journal of clinical medicine · 2025Article
- Subjective Monitoring in Under-20 Soccer Athletes: Affective, Load, Monotony, and Sleep Variations throughout a Competitive Cycle.Clinical practice and epidemiology in mental health : CP & EMH · 2025Article
- Cardiopulmonary Resilience in Highly Active Individuals: Pre-Post COVID-19 Cardiopulmonary Exercise Testing Analysis.Arquivos brasileiros de cardiologia · 2025Article
- Long-term course and factors influencing work ability and return to work in post-COVID patients 12 months after inpatient rehabilitation.Journal of occupational medicine and toxicology (London, England) · 2024Article
- Potential hypothesis for the increased risk of Parkinson´s disease following COVID-19.Molecular biology reports · 2024Review
- Tailored Physical Activity Interventions for Long COVID: Current Approaches and Benefits-A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- Exercise immunology: Novel insights.Journal of sport and health science · 2024Article
- The Role of Diet and Physical Activity in Shaping COVID-19 Severity: Design, Validation, and Application of a Retrospective Questionnaire.Healthcare (Basel, Switzerland) · 2024Article
- The intervention design to promote active travel mode among children and adolescents: A systematic review.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among coronavirus disease 2019 (COVID-19) patients, physically active individuals may be at lower risk of fatal outcomes. However, to date, no meta-analysis has been carried out to investigate the relationship between physical activity (PA) and fatal outcomes in patients with COVID-19. Therefore, this meta-analysis aims to explore the hospitalisation, intensive care unit (ICU) admissions, and mortality rates of COVID-19 patients with a history of PA participation before the onset of the pandemic, and to evaluate the reliability of the evidence. A systematic search of MEDLINE/PubMed, Cumulative Index to Nursing and Allied Health Literature, Scopus, and medRxiv was conducted for articles published up to January 2022. A random-effects meta-analysis was performed to compare disease severity and mortality rates of COVID-19 patients in physically active and inactive cases. Twelve studies involving 1,256,609 patients (991,268 physically active and 265,341 inactive cases) with COVID-19, were included in the pooled analysis. The overall meta-analysis compared with inactive controls showed significant associations between PA with reduction in COVID-19 hospitalisation (risk ratio (RR) = 0.58, 95% confidence intervals (CI) 0.46-0.73, P = 0.001), ICU admissions (RR = 0.65, 95% CI 0.52-0.81, P = 0.001) and mortality (RR = 0.47, 95% CI 0.38-0.59, P = 0.001). The protective effect of PA on COVID-19 hospitalisation and mortality could be attributable to the types of exercise such as resistance exercise (RR = 0.27, 95% CI 0.15-0.49, P = 0.001) and endurance exercise (RR = 0.41, 95% CI 0.23-0.74, P = 0.003), respectively. Physical activity is associated with decreased hospitalisation, ICU admissions, and mortality rates of patients with COVID-19. Moreover, COVID-19 patients with a history of resistance and endurance exercises experience a lower rate of hospitalisation and mortality, respectively. Further studies are warranted to determine the biological mechanisms underlying these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.