ArticleJournal of the American Geriatrics Society2022
Long-term sex differences in all-cause and infection-specific mortality post hip fracture.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Red cell distribution width and modified 5-item frailty index to predict short-term mortality in patients undergoing surgery for hip fracture.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Secondary fracture prevention after vertebral, femur or pelvic fracture at US academic medical center.Archives of osteoporosis · 2026Article
- Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.Medical sciences (Basel, Switzerland) · 2025Review
- Association Between Prehip Fracture Antidepressant Use and Posthip Fracture Length of Hospital Stay in Medicare Beneficiaries and Assessing Sex Differences.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice.Journal of cachexia, sarcopenia and muscle · 2025Article
- The impact of hip fracture on resilience in health-related quality of life: a cohort study.European geriatric medicine · 2025Article
- Predictors of 1-year mortality in a clinical cohort of hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Partial weight bearing and long-term survival outcomes in extracapsular hip fractures treated with trochanteric Gamma3 nails.BMC musculoskeletal disorders · 2025Article
- Association between pre-hip fracture depression and days at home after fracture and assessing sex differences.Journal of the American Geriatrics Society · 2024Article
- Predictors of long-term mortality in older patients with hip fractures managed by hemiarthroplasty: a 10-year study based on a population registry in Saxony, Germany.Patient safety in surgery · 2024Article
- Sex differences in mobility recovery after hip fracture: a time series analysis.Frontiers in public health · 2024Article
- Longitudinal characteristics of physical frailty and its components in men and women post hip fracture.Journal of the American Geriatrics Society · 2024Article
- Associations of sex, Alzheimer's disease and related dementias, and days alive and at home among older Medicare beneficiaries recovering from hip fracture.Journal of the American Geriatrics Society · 2023Article
- Hip fracture incidence and post-fracture mortality in Victoria, Australia: a state-wide cohort study.Archives of osteoporosis · 2023Article
- All-cause mortality risk in older patients with femoral neck fracture.BMC musculoskeletal disorders · 2022Article
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9 authors.
Funding
Abstract
backgroundMortality rates among men are double that of women in the first 2 years after hip fracture and may be related to more infections. Research has only examined differences in short-term mortality after hip fracture. Thus, the objective was to determine if long-term all-cause mortality and infection-specific mortality rates are higher in men compared to women.
methodsData come from a prospective cohort study (Baltimore Hip Studies 7th [BHS-7]) with up to 10.2 years of follow-up (2006-2018). The participants were selected from eight acute care hospitals in the 25-hospital BHS network. Enrolled women were frequency-matched (1:1) to men on timing of admission for hip fracture that yielded an analytic sample size of 300 participants (155 women, 145 men). Associations between sex and mortality were analyzed using Cox proportional hazard models and cause-specific Cox models adjusted for age, cognition, body mass index, pre-fracture lower extremity activities of daily living limitation, depressive symptoms, and comorbidity.
resultsParticipants had a mean age of 80 years, 48% (n = 145) were men and the median follow-up was 4.9 (interquartile range = 2.3-8.7) years. Over the follow-up period after hospital admission for hip fracture, 237 (79.0%) participants died of all causes (132 men and 105 women) and 38 (12.7%) died of infection-specific causes (25 men and 13 women). Men had significantly higher rates of all-cause mortality [hazard ratio (HR) = 2.31(95% confidence interval [CI] 2.02-2.59)] and infection-specific mortality (HR = 4.43, CI 2.07-9.51) compared to women.
conclusionsMen had a two-fold higher rate of all-cause mortality and four-fold higher rate of infection-specific mortality compared to women over a follow-up period of up to 10.2 years. Findings suggest that interventions to prevent and treat infections, tailored by sex, may be needed to narrow significant differences in long-term mortality rates between men and women after hip fracture.
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