Evidence map›Paper›PMID 35415875›Full record

ArticleJournal of applied clinical medical physics2022

MR relaxation times of agar-based tissue-mimicking phantoms.

Anastasia Antoniou, Leonidas Georgiou, Theodora Christodoulou, Natalie Panayiotou, Cleanthis Ioannides, Nikolaos Zamboglou, Christakis Damianou

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  4. Multimodal HSI-MRI system for tumor delineation in neurosurgical guidance.International journal of computer assisted radiology and surgery · 2026
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  7. Simple Frame-based Approach for MR Imaging-guided Abdominal Biopsy: Preliminary Evaluation in a Phantom Model.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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  11. Minimally Invasive Bowel Cancer Detection through Vibrating Microrobot-Induced Elastography.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025
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  13. Development of estimation method for TRadiological physics and technology · 2025
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  14. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  15. FeClMagma (New York, N.Y.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anastasia AntoniouDepartment of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.
Leonidas GeorgiouDepartment of Interventional Radiology, German Oncology Center, Limassol, Cyprus.
Theodora ChristodoulouDepartment of Interventional Radiology, German Oncology Center, Limassol, Cyprus.
Natalie PanayiotouDepartment of Interventional Radiology, German Oncology Center, Limassol, Cyprus.
Cleanthis IoannidesDepartment of Interventional Radiology, German Oncology Center, Limassol, Cyprus.
Nikolaos ZamboglouDepartment of Interventional Radiology, German Oncology Center, Limassol, Cyprus.
Christakis DamianouDepartment of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agar gels were previously proven capable of accurately replicating the acoustical and thermal properties of real tissue and widely used for the construction of tissue-mimicking phantoms (TMPs) for focused ultrasound (FUS) applications. Given the current popularity of magnetic resonance-guided FUS (MRgFUS), we have investigated the MR relaxation times T1 and T2 of different mixtures of agar-based phantoms. Nine TMPs were constructed containing agar as the gelling agent and various concentrations of silicon dioxide and evaporated milk. An agar-based phantom doped with wood powder was also evaluated. A series of MR images were acquired in a 1.5 T scanner for T1 and T2 mapping. T2 was predominantly affected by varying agar concentrations. A trend toward decreasing T1 with an increasing concentration of evaporated milk was observed. The addition of silicon dioxide decreased both relaxation times of pure agar gels. The proposed phantoms have great potential for use with the continuously emerging MRgFUS technology. The MR relaxation times of several body tissues can be mimicked by adjusting the concentration of ingredients, thus enabling more accurate and realistic MRgFUS studies.

Indexed as

Magnetic Resonance ImagingSilicon DioxideAgarGelsHumansPhantoms, ImagingAgarGelsSilicon DioxideagarMRgFUSMR relaxation timestissue-mimicking phantoms

Identifiers

PMID35415875
PMCPMC9121050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.