Evidence map›Paper›PMID 35415605›Full record

ArticleBrain communications2022

Epileptic discharges initiate from brain areas with elevated accumulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.

Tomoyuki Miyazaki, Yutaro Takayama, Masaki Iwasaki, Mai Hatano, Waki Nakajima, Naoki Ikegaya, Tetsuya Yamamoto, Shohei Tsuchimoto, Hiroki Kato, Takuya Takahashi

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Dosimetry and kinetic modelling of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tomoyuki MiyazakiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yutaro TakayamaDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira 187-8551, Japan.
Masaki IwasakiDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira 187-8551, Japan.
Mai HatanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Naoki IkegayaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tetsuya YamamotoDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Shohei TsuchimotoDivision of System Neuroscience, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
Hiroki KatoDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0000-0001-6523-0622
Yokohama City University · JPNational Center of Neurology and Psychiatry · JPNational Institute for Physiological Sciences · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presurgical identification of the epileptogenic zone is a critical determinant of seizure control following surgical resection in epilepsy. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor is a major component of neurotransmission. Although elevated α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor levels are observed in surgically resected brain areas of patients with epilepsy, it remains unclear whether increased α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor-mediated currents initiate epileptic discharges. We have recently developed the first PET tracer for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, [

Indexed as

AMPA receptorequivalent current dipoleintracranial electroencephalogrammagnetoencephalographypositron emission tomography

Identifiers

PMID35415605
PMCPMC8994107
OpenAlexW4210612923

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.