Evidence map›Paper›PMID 35415341›Full record

ArticleACS omega2022

Synthesis of Substituted Cy5 Phosphoramidite Derivatives and Their Incorporation into Oligonucleotides Using Automated DNA Synthesis.

Adam Meares, Kimihiro Susumu, Divita Mathur, Sang Ho Lee, Olga A Mass, Jeunghoon Lee, Ryan D Pensack, Bernard Yurke, William B Knowlton, Joseph S Melinger and 1 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Tunable Molecular Photonic Wires via Geometric Control of Excitonically Coupled Cyanine Dimer Relays.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026
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  9. Tunable Electronic Structure via DNA-Templated Heteroaggregates of Two Distinct Cyanine Dyes.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Adam MearesCenter for Bio/Molecular Science and Engineering Code 6900, U. S. Naval Research Laboratory, Washington, D.C., Virginia 20375, United States.ORCID https://orcid.org/0000-0002-0283-2578
Kimihiro SusumuOptical Sciences Division Code 5600, U. S. Naval Research Laboratory, Washington, D.C., Virginia 20375, United States.ORCID https://orcid.org/0000-0003-4389-2574
Divita MathurCenter for Bio/Molecular Science and Engineering Code 6900, U. S. Naval Research Laboratory, Washington, D.C., Virginia 20375, United States.ORCID https://orcid.org/0000-0002-3537-7292
Sang Ho LeeOptical Sciences Division Code 5600, U. S. Naval Research Laboratory, Washington, D.C., Virginia 20375, United States.
Olga A MassMicron School of Materials Science & Engineering, Boise State University, Boise, Idaho 83725, United States.ORCID https://orcid.org/0000-0002-2309-2644
Jeunghoon LeeMicron School of Materials Science & Engineering, Boise State University, Boise, Idaho 83725, United States.ORCID https://orcid.org/0000-0002-1909-4591
Ryan D PensackMicron School of Materials Science & Engineering, Boise State University, Boise, Idaho 83725, United States.ORCID https://orcid.org/0000-0002-1302-1770
Bernard YurkeMicron School of Materials Science & Engineering, Boise State University, Boise, Idaho 83725, United States.ORCID https://orcid.org/0000-0003-3913-2855
William B KnowltonMicron School of Materials Science & Engineering, Boise State University, Boise, Idaho 83725, United States.ORCID https://orcid.org/0000-0003-3018-2207
Joseph S MelingerElectronics Science and Technology Division Code 6800, U.S. Naval Research Laboratory, Washington, D.C. 20375, United States.ORCID https://orcid.org/0000-0002-2452-5245
Igor L MedintzCenter for Bio/Molecular Science and Engineering Code 6900, U. S. Naval Research Laboratory, Washington, D.C., Virginia 20375, United States.ORCID https://orcid.org/0000-0002-8902-4687
United States Naval Research Laboratory · USMicron (United States) · US

Funding

Cytosolic Access and Instability of DNA nanoparticlesK99EB030013 · NIBIB · GEORGE MASON UNIVERSITY · PI MATHUR, DIVITA · 2021 to 2022
$186k
NIBIB NIH HHS K99 EB030013
6 · The paper itself

Abstract

Cyanine dyes represent a family of organic fluorophores with widespread utility in biological-based applications ranging from real-time PCR probes to protein labeling. One burgeoning use currently being explored with indodicarbocyanine (Cy5) in particular is that of accessing exciton delocalization in designer DNA dye aggregate structures for potential development of light-harvesting devices and room-temperature quantum computers. Tuning the hydrophilicity/hydrophobicity of Cy5 dyes in such DNA structures should influence the strength of their excitonic coupling; however, the requisite commercial Cy5 derivatives available for direct incorporation into DNA are nonexistent. Here, we prepare a series of Cy5 derivatives that possess different 5,5'-substituents and detail their incorporation into a set of DNA sequences. In addition to varying dye hydrophobicity/hydrophilicity, the 5,5'-substituents, including hexyloxy, triethyleneglycol monomethyl ether,

Identifiers

PMID35415341
PMCPMC8991898
OpenAlexW4220849689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.