ArticleBioactive materials2022
Long-term safety and absorption assessment of a novel bioresorbable nitrided iron scaffold in porcine coronary artery.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed.
- Firesorb bioresorbable scaffold for de novo coronary artery disease: 1-year clinical outcomes.BMC medicine · 2025Trial
- Case Report: The "metal ring" phenomenon: a rare cause of recurrent in-stent restenosis.Frontiers in cardiovascular medicine · 2026Article
- Evaluation of FeMnN alloy bioresorbable flow diverting stents in the rabbit abdominal aorta.Bioactive materials · 2025Article
- Biodegradable Stents in the Treatment of Arterial Stenosis.Journal of clinical medicine · 2025Review
- Semi-quantitative elemental imaging of corrosion products from bioabsorbable Mg vascular implantsBioactive materials · 2025Article
- Enhancing radial strength and expansion uniformity of iron-based vascular scaffolds: a numerical and experimental investigation on topological optimization.Frontiers in bioengineering and biotechnology · 2025Article
- Research on the application of biomaterial-based responsive hydrogels in the tumor microenvironment.PeerJ · 2025Review
- A novel iron bioresorbable scaffold: a potential strategy for pulmonary artery stenosis.Regenerative biomaterials · 2025Article
- A Review of Additive Manufacturing of Biodegradable Fe and Zn Alloys for Medical Implants Using Laser Powder Bed Fusion (LPBF).Materials (Basel, Switzerland) · 2024Review
- Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration.Materials today. Bio · 2024Review
- Radiopaque FeMnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices.Bioactive materials · 2024Article
- Biodegradable high-nitrogen iron alloy anastomotic staples:Bioactive materials · 2024Article
- Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels.Nature communications · 2024Article
- Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- FeMaterials today. Bio · 2024Article
- Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook.Frontiers in cardiovascular medicine · 2024Review
- Fe-Zn alloy, a new biodegradable material capable of reducing ROS and inhibiting oxidative stress.Regenerative biomaterials · 2024Article
- Bioresorbable coronary scaffolds are ready for a comeback: pros and cons.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Immune response differences in degradable and non-degradable alloy implants.Bioactive materials · 2023Review
- Coronary artery spasm treated with intracoronary bioresorbable scaffold implantation under the guidance of treadmill test and optical coherence tomography: A case report.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the long-term biocompatibility, safety, and degradation of the ultrathin nitrided iron bioresorbable scaffold (BRS) in vivo, encompassing the whole process of bioresorption in porcine coronary arteries. Fifty-two nitrided iron scaffolds (strut thickness of 70 μm) and 28 Vision Co-Cr stents were randomly implanted into coronary arteries of healthy mini-swine. The efficacy and safety of the nitrided iron scaffold were comparable with those of the Vision stentwithin 52 weeks after implantation. In addition, the long-term biocompatibility, safety, and bioresorption of the nitrided iron scaffold were evaluated by coronary angiography, optical coherence tomography, micro-computed tomography, scanning electron microscopy, energy dispersive spectrometry and histopathological evaluations at 4, 12, 26, 52 weeks and even at 7 years after implantation. In particular, a large number of struts were almost completely absorbed in situ at 7 years follow-up, which were first illustrated in this study. The lymphatic drainage pathway might serve as the potential clearance way of iron and its corrosion products.
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