ArticleOpen forum infectious diseases2022
Prevalence of Frailty and Prefrailty in People With Human Immunodeficiency Virus Aged 50 or Older: A Systematic Review and Meta-Analysis.
Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07486661 (A Pilot Project for PLWH Aged 65-75), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Project for PLWH Aged 65-75: Preventing the Development of Frailty
Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.Age and ageing · 2026Trial
- Comprehensive geriatric assessment for people living with HIV and frailty: A mixed-methods feasibility randomized controlled trial.HIV medicine · 2026Trial
- Article
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- Article
- Interventions and opportunities to enhance aging among people with HIV: a focus on frailty, sarcopenia, and intrinsic capacity.Topics in antiviral medicine · 2026Review
- Prediction Models for Frailty in People Living With HIV: Protocol for a Systematic Review and Meta-Analysis of Prognostic Models.JMIR research protocols · 2026Article
- Frailty Transition Among Older Adults Living With HIV in Thailand: A 5-Year Longitudinal Study.Journal of the International AIDS Society · 2026Observational
- Prevalence and factors associated with frailty among older adults with and without HIV in Kampala, Uganda.AIDS research and therapy · 2025Article
- Sedative co-medication patterns across frailty states in people with HIV: a network-based study.International journal of clinical pharmacy · 2025Article
- Article
- Frailty integration in medical specialties: Current evidence and suggested strategies from the Clin-STAR frailty interest group.Journal of the American Geriatrics Society · 2025Review
- Cardiometabolic disease among frailty phenotype clusters in adults aging with HIV.The Journal of frailty & aging · 2025Article
- Building Research Infrastructure to Address Psychosocial Frailty and Reach Underserved Aging Populations.Journal of psychosocial nursing and mental health services · 2025Article
- Prevalence, factors and quality of life associated with frailty and pre-frailty in middle-aged and older adults living with HIV in Zimbabwe: A cross-sectional study.HIV medicine · 2025Article
- Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.Alcohol research : current reviews · 2025Review
- Experiences, Challenges, and Needs of People Living with HIV in Hunan Province, China: A Qualitative Study.Journal of multidisciplinary healthcare · 2025Article
- Area Deprivation Index and Frailty Among Older People With HIV.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- The Performance of a New Multidimensional Frailty Index in Comparison to the Frailty Phenotype to Assess Frailty in People Living with HIV 50 Years of Age and Older in an Urban HIV Clinic.Journal of AIDS and HIV treatment · 2025Article
- Unraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysis.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With effective antiretroviral therapy, there is an emerging population of adults aged 50 years or older with human immunodeficiency virus (HIV). Frailty is an increasingly recognized clinical state of vulnerability associated with disability, hospitalization, and mortality. However, there is a paucity of large studies assessing its prevalence in people with HIV (PWH) aged 50 or older. Methods: PubMed was systematically searched for studies published between January 2000 and August 2020 reporting the prevalence of frailty in PWH aged 50 or older. The pooled prevalence of frailty and prefrailty was synthesized using a random-effects meta-analysis. Results: Of the 425 studies identified, 26 studies were included in the analysis, with a total of 6584 PWH aged 50 or older. The included studies were published between 2012 and 2020, and all studies used the Fried frailty phenotype to define frailty. The overall pooled prevalence of frailty and prefrailty was 10.9% (95% confidence interval [CI], 8.1%-14.2%) and 47.2% (95% CI, 40.1%-54.4%), respectively. A high degree of heterogeneity was observed (I Conclusions: The pooled prevalence of frailty and prefrailty defined by the Fried frailty phenotype was assessed in PWH aged 50 or older. Findings from this study quantified the proportion of this specific population with this common geriatric syndrome. Future studies identifying effective strategies for frailty screening and intervention are required for this vulnerable population.
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