ArticleCureus2022
A Rare Case of HHV-6 Encephalitis in an Immunocompetent Host: Case Report and Literature Review.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Atypical manifestation of human herpes virus-6 encephalitis with extra-limbic lesions: a case report.Encephalitis (Seoul, Korea) · 2026Article
- HHV-6-induced hydrocephalus with ventricular septa formation in an immunocompetent adult: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Acute Meningitis/Encephalitis Presumably Secondary to Human Herpesvirus 6: A Case Report.Cureus · 2025Article
- Article
- Article
- Article
- Diagnostic Dilemmas: A Review of Reported Cases of Human Herpesvirus 6 Encephalitis in Immunocompetent Adults.Open forum infectious diseases · 2024Review
- Human Herpesvirus 6-A Rare Aetiologic Agent for CNS Infections in Immunocompetent Individuals or an Underestimation?Journal of clinical medicine · 2024Article
- Human herpesvirus-6 infection in a critically ill and immunocompetent patient: a case report.Journal of medical case reports · 2024Article
- Article
- HHV-6 Meningoencephalitis in a Healthy Adult Female.Case reports in emergency medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human herpesvirus-6 (HHV-6) is a virus known for causing the highly contagious infection, roseola infantum, and has been associated with causing encephalitis in pediatric patients and less commonly in adult patients as well. Regardless of the patient's age, the primary HHV-6 infection could be complicated by neurological sequelae including encephalitis, acute encephalopathy with biphasic seizures syndrome, or demyelinating disease. HHV-6 encephalitis does occur in an adult as a primary infection or reactivation. However, immunocompromised, hematopoietic stem cell transplantation patients, and solid organ transplant recipients are the most affected population. Here we present a rare case of HHV-6 encephalitis in a 26-year-old healthy immunocompetent male. HHV-6 viral DNA was detected in the cerebrospinal fluid during the acute stage of the disease, and the diagnosis was confirmed by quantitative polymerase chain reaction (PCR). The patient was treated with ganciclovir and had a complete response to treatment without any further complication. The pathophysiology, clinical course, and treatment in otherwise immunocompetent adult patients are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.