Evidence map›Paper›PMID 35415017›Full record

ArticlePeerJ2022

The regulation of hsacirc_004413 promotes proliferation and drug resistance of gastric cancer cells by acting as a competing endogenous RNA for miR-145-5p.

Fusheng Zhou, Weiqun Ding, Qiqi Mao, Xiaoyun Jiang, Jiajie Chen, Xianguang Zhao, Weijia Xu, Jiaxin Huang, Liang Zhong, Xu Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fusheng Zhou *Department of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Weiqun Ding *Department of Gastroenterology, Huashan Hospital, Fudan University, Shanghai, China.
Qiqi MaoDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Xiaoyun JiangDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Jiajie ChenDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Xianguang ZhaoDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Weijia XuDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Jiaxin HuangDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Liang ZhongDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Xu SunDepartment of Gastroenterology, Huashan Hospital North, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Whether circRAN, which acts as a microRNA sponge, plays a role in 5-fluorouracil (5-Fu) resistant gastric cancer has not been reported. In this study, a 5-Fu resistant cell line with an IC50 of 16.59 µM was constructed. Methods: Using comparative analysis of circRNA in the transcriptomics of resistant and sensitive strains, 31 differentially expressed circRNAs were detected, and the microRNA interacting with them was predicted. Results: Hsacirc_004413 was selected for verification in drug resistant and sensitive cells. By interfering with hsacirc_004413 using antisense RNA, the sensitivity of drug resistant cells to 5-Fu was significantly promoted, and the apoptosis and necrosis of the cells were significantly increased. In sensitive cells, inhibition by inhibitors enhanced the resistance of cells to 5-Fu. We hypothesize that hsacirc_004413 makes gastric cancer cells resistant to 5-Fu mainly through adsorption of miR-145-5p.

Indexed as

MicroRNAsStomach NeoplasmsCell Line, TumorCell ProliferationDrug Resistance, NeoplasmFluorouracilHumansRNA, CircularFluorouracilMicroRNAsMIRN145 microRNA, humanRNA, Circular5-FuCircRANDrug resistanceGastric carcinoma cells

Identifiers

PMID35415017
PMCPMC8995023
OpenAlexW4225712229

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.