Evidence map›Paper›PMID 35415000›Full record

ArticleBiomedical optics express2022

Visualization of blood-brain barrier disruption with dual-wavelength high-resolution photoacoustic microscopy.

Yongchao Wang, Ruoxi Zhang, Qian Chen, Heng Guo, Xiao Liang, Tingting Li, Weizhi Qi, Lei Xi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yongchao WangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.ORCID https://orcid.org/0000-0002-6637-0157
Ruoxi ZhangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Qian ChenDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Heng GuoDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Xiao LiangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Tingting LiDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Weizhi QiDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Lei XiDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.ORCID https://orcid.org/0000-0002-2598-6801
Southern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) strictly regulates the substance exchange between the vascular network and the central nervous system, and plays a critical role in maintaining normal brain homeostasis. Impaired BBB is often accompanied with the emergence of cerebral diseases and probably further leads to severe neuroinflammation or even neurological degeneration. Hence, there is an urgent need to precisely monitor the impaired BBB to understand its pathogenesis and better guide the enactment of therapeutic strategies. However, there is a lack of high-resolution imaging techniques to visualize and evaluate the large-scale BBB disruption in pre-clinical and clinical aspects. In this study, we propose a dual-wavelength photoacoustic imaging (PAI) methodology that simultaneously reveals the abnormal microvasculature and impaired BBB within the cerebral cortex. In

Identifiers

PMID35415000
PMCPMC8973185
OpenAlexW4210793763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.