ArticleBiomedical optics express2022
Imaging of vitreous cortex hyalocyte dynamics using non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy in human subjects.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The trial behind it
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Who cites it
47 citing papers in PubMed, 57 citations in OpenAlex.
- Characterization of Leukocyte Crawling in the Living Human Retina Using Adaptive Optics Scanning Light Ophthalmoscopy.Investigative ophthalmology & visual science · 2026Article
- Reflective broadband adaptive optics scanning light ophthalmoscope with 20 D focus range.Biomedical optics express · 2026Article
- Multi-orientation non-confocal retinal imaging in an AOSLO using a Dove prism.Biomedical optics express · 2026Article
- [A look at the vitreous body, not through it: anatomy, embryology and cells of the vitreous body].Die Ophthalmologie · 2026Article
- Single wavelength, dual temporal offset module for AOSLO systems.Biomedical optics express · 2026Article
- Principles of resident tissue macrophages revealed by the eye.Advances in immunology · 2026Review
- Evaluating the quantity and spatial density of macrophage-like cells in patients with retinal vascular disease and healthy subjects via non-invasive retinal imaging.International journal of retina and vitreous · 2025Article
- Distribution and dynamics of motile immune cells near the inner limiting membrane in the living human eye.Biomedical optics express · 2025Article
- Wide-field choriocapillaris mapping with 3.4 MHz adaptive optics-optical coherence tomography angiography.Biomedical optics express · 2025Article
- Telecentric model eye for correction of image distortion in adaptive optics ophthalmoscopes.Biomedical optics express · 2025Article
- Enhanced genotype-phenotype analysis using multimodal adaptive optics and 3D protein structure in Bietti Crystalline Dystrophy.American journal of ophthalmology case reports · 2025Article
- Deep compressed multichannel adaptive optics scanning light ophthalmoscope.Science advances · 2025Article
- Elevated hyperreflective foci as a novel characteristic in idiopathic epiretinal membrane by optical coherence tomography angiography.BMC ophthalmology · 2025Article
- Quantification of optical lensing by cellular structures in the living human eye.Biomedical optics express · 2025Article
- Ultrastructural investigation of the posterior hyaloid membrane in posterior vitreous detachment.Eye (London, England) · 2025Article
- Redefining our vision: an updated guide to the ocular immune system.Nature reviews. Immunology · 2024Review
- Ultrafast adaptive optics for imaging the living human eye.Nature communications · 2024Article
- The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy.Journal of neuroinflammation · 2024Article
- Improved tracking of corneal immune cell dynamics usingBiomedical optics express · 2024Article
- Improving cone identification using merged non-confocal quadrant-detection adaptive optics scanning light ophthalmoscope images.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Vitreous cortex hyalocytes are resident macrophage cells that help maintain the transparency of the media, provide immunosurveillance, and respond to tissue injury and inflammation. In this study, we demonstrate the use of non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy (AOSLO) to non-invasively visualize the movement and morphological changes of the hyalocyte cell bodies and processes over 1-2 hour periods in the living human eye. The average velocity of the cells 0.52 ± 0.76 µm/min when sampled every 5 minutes and 0.23 ± 0.29 µm/min when sampled every 30 minutes, suggesting that the hyalocytes move in quick bursts. Understanding the behavior of these cells under normal physiological conditions may lead to their use as biomarkers or suitable targets for therapy in eye diseases such as diabetic retinopathy, preretinal fibrosis and glaucoma.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.