ArticleInternational journal of clinical and experimental pathology2022
Pathologic mechanism of hidden blood loss after total knee arthroplasty: oxidative stress induced by free fatty acids.
Article in International journal of clinical and experimental pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and Safety of Oxidized Regenerated Cellulose for Hemostasis in Joint Arthroplasty: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Efficacy and Safety of Bone Wax Application at Different Time Points to Reduce Postoperative Blood Loss in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.Orthopaedic surgery · 2024Trial
- Hemostatic effect and safety evaluation of oxidized regenerated cellulose in total knee arthroplasty- a randomized controlledtrial.BMC musculoskeletal disorders · 2023Trial
- Hidden blood loss estimation using perioperative hemoglobin drop: agreement with the Sehat formula.BMC surgery · 2026Article
- Knowledge, attitude, and practices of nurses toward the assessment and management of perioperative hidden blood loss among orthopedic patients: A cross-sectional multicenter study.Scientific reports · 2026Article
- Predictors and Early Outcomes of Hidden Blood Loss Following Surgery for Spinal Metastases: A Retrospective Study Focusing on Tomita Type 1-5 Lesions.Journal of clinical medicine · 2026Article
- The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials.The archives of bone and joint surgery · 2026Review
- Novel fat infiltration combined with muscle parameters for predicting postoperative complications following total knee arthroplasty: a retrospective study.BMC musculoskeletal disorders · 2025Article
- Postoperative Changes in Hematological, Biochemical, and Redox Status Parameters in Spinal Osteoarthritis Patients Undergoing Spinal Decompression and Stabilization Surgery.Journal of clinical medicine · 2025Article
- Ascorbic Acid Reduces the Blood Boss After Total Knee Arthroplasty: Insights From a Randomized Controlled Trial.Arthroplasty today · 2025Article
- J-shaped association of operation duration and blood transfusion risk in patients undergoing primary total knee arthroplasty.International orthopaedics · 2024Article
- Hemostatic effect of oxidized regenerated cellulose vs. topical tranexamic acid in total knee arthroplasty-a prospective randomized controlled trial.Frontiers in surgery · 2024Article
- Risk Factors Analysis and Nomogram Model Establishment of Hidden Blood Loss in Overweight and Obese Elderly Patients After Total Hip Arthroplasty.Clinical interventions in aging · 2024Article
- Safety and Efficacy of a Novel Hemostatic Powder in Total Knee Arthroplasty.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHidden blood loss (HBL) often occurs after joint replacement; however, the mechanism of HBL is not clear. We conducted a prospective study to analyze the correlation between high-level free fatty acids (FFA) and erythrocyte injury, and explore the pathologic mechanism of hidden blood loss (HBL) after total knee arthroplasty (TKA).
methodsPerioperative blood indexes were tested in 120 patients who underwent unilateral total knee replacement for end-stage knee osteoarthritis. The changes in FFA, reactive oxygen species (ROS), hemoglobin (Hb), and red blood cells (RBC) in the blood samples were detected. The activity of glutathione peroxidase (GSH-Px), total superoxide dismutase (T-SOD) and hydrogen peroxide (H
resultsHBL occurred in all patients after TKA. The Hb and RBC decreased significantly 24 h after surgery (
conclusionsHigh levels of FFA in blood can induce oxidative stress and damage red blood cells, leading to the occurrence of HBL after surgery.
trial registrationChinese Clinical Trials Registry (the trial number: ChiCTR17010681, URL: http://www.chictr.org.cn).
Indexed as
Identifiers
35414844PMC8986472What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.