Evidence map›Paper›PMID 35414769›Full record

ArticleInternational journal of biological sciences2022

Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway.

Zhenzhen Zhang, Tiantian Yao, Nan Zhao, Hui Liu, Hao Cheng, Frank J Gonzalez, Hua Wang, Guiqiang Wang, Aijuan Qu, Yan Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhenzhen ZhangDepartment of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Tiantian YaoDepartment of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Nan ZhaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China.
Hui LiuDepartment of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Hao ChengDepartment of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, 20892, USA.
Hua WangDepartment of Pharmacy, Anhui Medical University; Department of Oncology, the First Affiliated Hospital, Institute for Liver Diseases of Anhui Medical University, Hefei, 230032, China.
Guiqiang WangDepartment of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Aijuan QuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China.
Yan WangDepartment of Infectious Diseases, Peking University First Hospital, Beijing, 100034, China.
Peking University First Hospital · CNBeijing YouAn Hospital · CNPeking University · CN

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chemical and Drug Induced Liver InjuryChemical and Drug Induced Liver Injury, ChronicAcetaminophenAnimalsCytochrome P-450 Enzyme SystemHepatocytesInterleukin-6LiverMiceMice, Inbred C57BLMice, KnockoutPPAR alphaSTAT3 Transcription FactorAcetaminophenCytochrome P-450 Enzyme SystemInterleukin-6PPAR alphaSTAT3 protein, humanSTAT3 Transcription FactorAcetaminophen (APAP)HepatotoxicityIL-6/STAT3Liver injuryLiver repairOxidative stressPeroxisome proliferator-activated receptor α (PPARα)

Identifiers

PMID35414769
PMCPMC8990472
OpenAlexW4225832289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.