ArticleReproductive medicine and biology
Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre-culture, insemination, and beyond.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Measuring progress in human ARTs: When the media speaks loud and clearly.Journal of assisted reproduction and genetics · 2026Article
- Rescue in vitro maturation of germinal vesicle oocytes after ovarian stimulation: the importance of the culture media.Human reproduction (Oxford, England) · 2025Article
- Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre-culture, insemination, and beyond.Reproductive medicine and biologyArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: We focused on the metabolism of oocytes in pre-culture and insemination and compared these results between our existing fertilization medium, GEMS Fertilisation Medium (GEMS group) (Merck BioPharma) and Continuous Single Culture Medium-NX Complete (CSCM-NXC group) (FUJIFILM Irvine Scientific). Methods: Patients under 42 years of age were received controlled ovarian stimulation and oocytes were retrieved. Those were pre-cultured and fertilized with either GEMS fertilization medium or CSCM-NXC. After fertilization was confirmed, embryos were cultured using CSCM-NXC in both groups. The embryos were cryopreserved at blastocyst stage (3BB or more, Gardner classification) and then transferred in HRT cycles. Results: The fertilization rate of both groups was the same, but the 3PN rate was significantly lower in the CSCM-NXC group. In terms of embryo culture results, the CSCM-NXC group had a significantly higher rate of good quality blastocysts, high-grade embryos, and embryos with a high degree of expansion. Conclusions: The use of CSCM-NXC, a low lactate embryo culture medium, from pre-culture and for insemination, increases the energy metabolic efficiency of oocytes and cumulus cells, making it possible to supply sufficient energy ATP for fertilization and early division, which is thought to promote good embryonic development.
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Registered trials
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