Evidence map›Paper›PMID 35414723›Full record

SynthesisPathologica2022

Malignant phyllodes tumor of the breast: a systematic review.

Germana Lissidini, Antonino Mulè, Angela Santoro, Giovanni Papa, Luca Nicosia, Enrico Cassano, Arwa Ahmed Ashoor, Paolo Veronesi, Liron Pantanowitz, Jason L Hornick and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Pathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Clinical case giant malignant phyllodes tumor of the breast.Journal of surgical case reports · 2026
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  14. Review
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  18. Case report: rapid growth of malignant phyllodes tumor.Journal of surgical case reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Germana LissidiniDivision of Breast Surgery, European Institute of Oncology, IRCCS, Milan, Italy.
Antonino MulèDivision of Anatomic Pathology and Histology Catholic University Rome, Italy.
Angela SantoroDivision of Anatomic Pathology and Histology Catholic University Rome, Italy.
Giovanni PapaDepartment of Medical, Surgical and Health Sciences, Plastic and Reconstructive Surgery Unit, University of Trieste, Trieste, Italy.
Luca NicosiaBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, Milan, Italy.
Enrico CassanoBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, Milan, Italy.
Arwa Ahmed AshoorBreast Unit, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Paolo VeronesiDivision of Breast Surgery, European Institute of Oncology, IRCCS, Milan, Italy.
Liron PantanowitzDepartment of Pathology & Clinical Labs, University of Michigan, Ann Arbor, Michigan USA.
Jason L HornickDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Esther Diana RossiDivision of Anatomic Pathology and Histology Catholic University Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phyllodes tumors (PT) are fibroepithelial neoplasms of the breast showing a peculiar leaf-like appearance. They account for 0.3 to 1% of all primary breast tumors and 2.5% of all fibroepithelial breast tumors. PT are classified into benign, borderline and malignant based upon their stromal morphology with a distribution of 60%, 20%, and 20%, respectively. Malignant PT of the breast constitute an uncommon challenging group of fibroepithelial neoplasms. They have a relatively high tendency to recur, although distant metastasis is uncommon, and nearly exclusive to malignant PT. Adequate surgical resection remains the standard approach to achieve maximal local control. Giant malignant PT are rare and a pose a diagnostic dilemma for pathologists, especially when comprised of sarcomatous elements. This review highlights the morphological features of PT detected in cytology and histology specimens and discusses diagnostic pitfalls and differential diagnosis.

Indexed as

Breast NeoplasmsNeoplasms, FibroepithelialPhyllodes TumorBreastFemaleHumansNeoplasm Recurrence, Localbreast diseasebreast oncologyfine needle aspirationmalignant phyllodes tumorpathologypersonalized medicinephyllodes tumor

Identifiers

PMID35414723
PMCPMC9248247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.