Evidence map›Paper›PMID 35414661›Full record

SynthesisEuropean journal of clinical nutrition2022

Phase angle of bioimpedance at 50 kHz is associated with cardiovascular diseases: systematic review and meta-analysis.

Evandro Lucas de Borba, Jamile Ceolin, Patrícia Klarmann Ziegelmann, Luiz Carlos Bodanese, Marcelo Rodrigues Gonçalves, Wilson Cañon-Montañez, Rita Mattiello

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Association between phase angle and self-rated health among Korean adults: a cross-sectional analysis from the 2022-2023 KNHANES.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  9. Article
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  13. Fat-Free Mass: Friend or Foe to Metabolic Health?Journal of cachexia, sarcopenia and muscle · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Evandro Lucas de BorbaPontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brasil.
Jamile CeolinPontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brasil.
Patrícia Klarmann ZiegelmannStatistics, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brasil.
Luiz Carlos BodanesePontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brasil.
Marcelo Rodrigues GonçalvesUniversidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brasil.
Wilson Cañon-MontañezFaculty of Nursing, Universidad de Antioquia, Medellín, Colombia.ORCID 0000-0003-0729-5342
Rita MattielloPontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brasil. rita.mattiello@pucrs.br.ORCID 0000-0002-0548-3342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phase angle of bioimpedance is an important prognostic tool in clinical practice. The aim of this study was to investigate the association between phase angle and cardiovascular diseases. Electronic searches were carried out on MEDLINE, EMBASE, Cochrane, SCIELO, LILACS, CINAHL, Scopus, and the Web of Science. The PECO was "P" adults over 18 years of age, "E" the presence of cardiovascular disease, "C" absence of cardiovascular disease, and "O" phase angle values. The phase-angle means difference (MD) was analyzed separately by sex. Subgroup metanalysis with age, body mass index, and heart failure disease and meta-regressions were analyzed with random-effects models. Sensitivity analysis was performed considering only studies with high quality. The heterogeneity among studies was assessed using the Q-Cochran test and I² statistics. Four-hundred-thirty-nine articles were identified, and 22 studies were included in this systematic review, totaling 10.010 participants. Eight studies met the criteria for the meta-analysis, involving 2164 participants. The phase angle (PA) was measured at 50 kHz frequency in all studies. Individuals with cardiovascular disease had a smaller PA compared to the control group, for both males (MD -0.70; 95% CI -1.01 to -0.39) and females (MD -0.76; 95% CI -1.39 to -0.13). In the sensitivity analysis, in men, the quality of studies (P < 0.01), and in women, heart failure (P < 0.01) was significantly different between groups.The values of the phase angle were lower in individuals with cardiovascular disease than in control subjects. This result reinforces the importance of this tool in clinical practice, highlighting its potential to assess health status. Registration: The systematic review protocol was registered in the PROSPERO database as CRD42020164178.

Indexed as

Cardiovascular DiseasesHeart FailureAdolescentAdultBody Mass IndexFemaleHumansMale

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.