ReviewOpen biology2022
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors.
Review in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Mitochondrial vulnerability to aldehydic load and the role mitochondrial aldehyde dehydrogenases.Pharmacological research · 2026Review
- Cell envelope maintenance by PhoP is essential forProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification of gene targets regulated by the IclR-like regulator SL1344_3500 inJournal of bacteriology · 2025Article
- TheeLife · 2025Article
- Article
- A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection.Nature communications · 2025Article
- Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis.PLoS pathogens · 2025Article
- Article
- Insights into Active Site Cysteine Residues inInternational journal of molecular sciences · 2025Review
- Identification of glyoxalase A in group BInfection and immunity · 2025Article
- Piperideine-6-carboxylic acid regulates vitamin B6 homeostasis and modulates systemic immunity in plants.Nature plants · 2025Article
- Decoding drug tolerance: insights into theFrontiers in microbiology · 2025Article
- Identification of Glyoxalase A in Group BbioRxiv : the preprint server for biology · 2024Article
- Article
- Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications.International journal of molecular sciences · 2024Review
- Contribution of infectious diseases to the selection of ADH1B and ALDH2 gene variants in Asian populations.Alcohol, clinical & experimental research · 2024Article
- Uncovering the roles ofmSphere · 2024Article
- Paleo-health of Neolithic wet-rice farmers in the Yangtze River Delta: a comparison with early millet farmers in northern China.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2024Article
- Aldehyde accumulation inmBio · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by an infected host is a previously unappreciated innate immune defence mechanism. While there has been a significant focus on the effects of aldehydes on mammalian physiology, the idea that they might be exploited or purposefully induced to kill pathogens is new. Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-γ) during infections, we hypothesize that aldehydes are among the arsenal of IFN-γ-inducible effectors needed for pathogen control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.