ReviewProceedings. Biological sciences2022
Sex determination systems as the interface between male-killing bacteria and their hosts.
Review in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Spiroplasma Are Protective Heritable Symbionts With Low Physiological Impact in the Drosophilid Fly Zaprionus kolodkinae.Environmental microbiology reports · 2026Article
- Establishment and characterization of a Wolbachia (wAlbB)-infected Aedes aegypti line (Tw-Kao) for dengue control.PLoS neglected tropical diseases · 2026Article
- Complete transition from chromosomal to cytoplasmic sex determination during prolonged Wolbachia symbiosis.Nature communications · 2026Article
- Endosymbionts interacting with sex-determining genes and processes.Current opinion in insect science · 2025Review
- Evolutionary Diversification and Functions of the Candidate Male Killing Gene wmk.Genome biology and evolution · 2025Article
- Prophage-encodedeLife · 2025Article
- Genomic analysis of co-infection withFrontiers in microbiology · 2025Article
- Cell-based assays and comparative genomics revealed the conserved and hidden effects ofPNAS nexus · 2024Article
- Describing endosymbiont-host interactions within the parasitism-mutualism continuum.Ecology and evolution · 2024Article
- With a little help from my friends: the roles of microbial symbionts in insect populations and communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Zygosity-based sex determination in a butterfly drives hypervariability ofScience advances · 2024Article
- Two male-killingRoyal Society open science · 2024Article
- Article
- Sexual antagonism in sequential hermaphrodites.Proceedings. Biological sciences · 2023Article
- Male-killing virus in a noctuid mothProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Combined actions of bacteriophage-encoded genes iniScience · 2023Article
- Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima.Applied and environmental microbiology · 2023Article
- Review
- A male-killing Wolbachia endosymbiont is concealed by another endosymbiont and a nuclear suppressor.PLoS biology · 2023Article
- Male-killer symbiont screening reveals novel associations inAccess microbiology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthropods host a range of sex-ratio-distorting selfish elements, including diverse maternally inherited endosymbionts that solely kill infected males. Male-killing heritable microbes are common, reach high frequency, but until recently have been poorly understood in terms of the host-microbe interaction. Additionally, while male killing should generate strong selection for host resistance, evidence of this has been scant. The interface of the microbe with host sex determination is integral to the understanding of how death is sex limited and how hosts can evolve evasion of male killing. We first review current knowledge of the mechanisms diverse endosymbionts use to induce male-specific death. We then examine recent evidence that these agents do produce intense selection for host nuclear suppressor elements. We argue, from our understanding of male-killing mechanisms, that suppression will commonly involve evolution of the host sex determination pathways and that the host's response to male-killing microbes thus represents an unrecognized driver of the diversity of arthropod sex determination. Further work is required to identify the genes and mechanisms responsible for male-killing suppression, which will both determine the components of sex determination (or other) systems associated with suppressor evolution, and allow insight into the mechanism of male killing itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.