ArticleCirculation. Cardiovascular imaging2022
Prognostic Relationship Between Coronary Artery Calcium Score, Perfusion Defects, and Myocardial Blood Flow Reserve in Patients With Suspected Coronary Artery Disease.
Article in Circulation. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 52 citations in OpenAlex.
- Hidden risk in normal myocardial perfusion scans: AI-detected proximal coronary calcium on CT attenuation maps improves prognosis.European journal of nuclear medicine and molecular imaging · 2026Article
- Ischemic Risk in Patients with Zero Coronary Artery Calcium Undergoing Stress PET/CT Testing.Journal of clinical medicine · 2026Article
- Observational
- Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.Cardiovascular diabetology · 2025Observational
- Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Does Sex or Age Impact the Prognostic Value of a Zero Coronary Artery Calcium Score?Journal of clinical medicine · 2025Article
- Coronary Computed Tomography Angiography Atherosclerotic Plaque Volume as A Predictor of Myocardial Blood Flow Impairment in Non-Obstructive Coronary Artery Disease.Reviews in cardiovascular medicine · 2025Article
- Interplay between subclinical calcified atherosclerosis and coronary microvascular dysfunction in patients with normal perfusion imaging.American heart journal plus : cardiology research and practice · 2025Article
- Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease.Cardiovascular diabetology · 2025Article
- Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study.European heart journal · 2025Article
- Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis.European journal of nuclear medicine and molecular imaging · 2025Article
- Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes.Scientific reports · 2025Article
- Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging.The international journal of cardiovascular imaging · 2024Article
- Hybrid nuclear/CT cardiac imaging: Pros cons and the future.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Coronary artery calcium score and pre-test probabilities as gatekeepers to predict and rule out perfusion defects in positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Coronary vascular dysfunction is associated with increased risk of death in patients with peripheral artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Coronary artery calcium score as a gatekeeper: are we there yet?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Future of Radionuclide Myocardial Perfusion Imaging: Transitioning from SPECT to PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Incremental prognostic value of stress phase entropy over standard PET myocardial perfusion imaging variables.European journal of nuclear medicine and molecular imaging · 2023Article
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11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCoronary artery calcium score (CACS) is an anatomic measure of calcified atherosclerosis. Myocardial perfusion defects and reduced myocardial blood flow reserve (MBFR) are physiological measures of ischemia and coronary circulatory health. We aimed to assess the relative prognostic importance of MBFR, perfusion defects, and CACS in patients with suspected coronary artery disease.
methodsA total of 5983 consecutive patients without known history of coronary artery disease or cardiomyopathy, who underwent a CACS and
resultsMean age was 67.1 years, 60% were female, and 83% were symptomatic. CACS was 0 in 22%, abnormal perfusion in 19%, and MBFR <2 in 53.3%. When added to RF, the model with MBFR had the best fit (c=0.78,
conclusionsUse of anatomic testing such as CACS of 0 to avoid myocardial perfusion imaging in symptomatic patients could lead to missing microvascular dysfunction in 4 out of 10 patients, a finding associated with a high mortality risk. Higher CACS was independently associated with the risk of death but did not provide incremental prognostic value over positron emission tomography with MBFR.
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