Evidence map›Paper›PMID 35414107›Full record

ArticleCommunications biology2022

Bovine host genome acts on rumen microbiome function linked to methane emissions.

Marina Martínez-Álvaro, Marc D Auffret, Carol-Anne Duthie, Richard J Dewhurst, Matthew A Cleveland, Mick Watson, Rainer Roehe

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 96 citations in OpenAlex.

  1. Article
  2. Host genetic regulation of rumen 6-hydroxymelatonin reduces methane emissions in dairy cattle.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  18. Methanogenesis inhibition remodels microbial fermentation and stimulates acetogenesis in ruminants.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Marina Martínez-ÁlvaroScotland's Rural College, Edinburgh, UK.ORCID 0000-0003-2295-5839
Marc D AuffretAgrifirm, Drongen, Belgium.
Carol-Anne DuthieScotland's Rural College, Edinburgh, UK.
Richard J DewhurstScotland's Rural College, Edinburgh, UK.ORCID 0000-0002-9357-7372
Matthew A ClevelandGenus plc, DeForest, WI, USA.
Mick WatsonThe Roslin Institute and the Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4211-0358
Rainer RoeheScotland's Rural College, Edinburgh, UK. Rainer.Roehe@sruc.ac.uk.ORCID 0000-0002-4880-3756
Scotland's Rural College · GBGenus (United States) · USRoslin Institute · GB

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/N01720X/1, BB/N016742/1, BB/S006567/1, BB/S006680/1
6 · The paper itself

Abstract

Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had significant host genomic effects (heritabilities ranging from 0.13 to 0.61), revealing that substantial variation of the microbiome is under host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (|0.59| to |0.93|) with emissions of the potent greenhouse gas methane (CH

Indexed as

MicrobiotaRumenAnimalsArchaeaCattleMetagenomeMethaneMethane

Identifiers

PMID35414107
PMCPMC9005536
OpenAlexW4223447477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.