ArticleTrials2022
Internet-based cognitive behavioral therapy for improving health-related quality of life in patients with endometriosis: study protocol for a randomized controlled trial.
Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05098444 (Endometriosis - Internet-based Therapy), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endometriosis - Internet-based Therapy (Ed.iTh): Evaluation of an Internet-based Cognitive Behavioral Treatment to Improve the Quality of Life With Endometriosis
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Psychological therapies delivered remotely for the management of chronic pain (excluding headache) in adults.The Cochrane database of systematic reviews · 2023Pooled it
- Online-CBT for endometriosis: Exploring the acceptability and impact of the Ed.iTh program.Internet interventions · 2026Article
- Online Cognitive-Behavioral Programs for Women Living With Endometriosis: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Exploring endometriosis community needs to co-create the EndoZone digital health platform: a qualitative research study.BMC women's health · 2025Article
- A review of treatment options for chronic pelvic pain from endometriosis.Pain management · 2025Review
- A Digital Program for Daily Life Management With Endometriosis: Pilot Cohort Study on Symptoms and Quality of Life Among Participants.JMIR formative research · 2025Article
- Holistic approaches to living well with endometriosis.F1000Research · 2024Review
- Understanding Psychological Symptoms of Endometriosis from a Research Domain Criteria Perspective.Journal of clinical medicine · 2023Review
- Using Personas in the development of eHealth interventions for chronic pain: A scoping review and narrative synthesis.Internet interventions · 2023Article
- Comprehensive endometriosis care: a modern multimodal approach for the treatment of pelvic pain and endometriosis.Therapeutic advances in reproductive healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe trial investigates the efficacy of internet-based cognitive behavioral therapy (iCBT) in improving health-related QoL in patients with endometriosis, which is a chronic gynecological condition affecting up to 15% of people with female-assigned reproductive organs. Endometriosis is stress-related and comes with various physical symptoms such as pelvic pain and infertility. It has a substantial impact on health-related quality of life (QoL), and mind-body interventions seem promising in reducing the psychological burden.
methodsThis is a monocentric randomized-controlled trial recruiting 120 patients with endometriosis. The intervention consists of eight iCBT modules focusing on psychoeducation, cognitive restructuring, pacing, and emotion regulation. Participants will receive written feedback from a trained therapist weekly. The comparator is a waitlist control group. All participants will be followed up 3 months after the intervention, and the intervention group will additionally be followed up 12 months after the intervention. Trial participants will not be blinded to the allocated trial arm. Primary outcome measures are endometriosis-related QoL, pain, and pain-related disability. Secondary outcomes include coping, illness representations, and psychological flexibility. Statistical analyses will be performed following intention-to-treat principles. DISCUSSION: This randomized-controlled trial is the first trial to test the efficacy of iCBT for improving endometriosis-related QoL. Potential predictor variables and key mechanisms in treatment will be investigated to enable further progression in medical and psychological care for patients with endometriosis.
trial registrationClinicalTrials.gov , NCT05098444 Registered on October 28, 2021.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.